Evidence map›Paper›PMID 35602475›Full record

ArticleFrontiers in medicine2022

Preliminary Study on the Combination Effect of Clindamycin and Low Dose Trimethoprim-Sulfamethoxazole on Severe

Zhun-Yong Gu, Wen-Jun Liu, Dan-Lei Huang, Yu-Jing Liu, Hong-Yu He, Cheng Yang, Yi-Mei Liu, Ming Xu, Rui-Ming Rong, Du-Ming Zhu and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04328688 (Clindamycin - Trimethoprim/Sulfamethoxazole for Pneumocystis Jiroveci Pneumonia After Solid Organ Transplantation Population), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04328688 completednot on this map

Clindamycin - Trimethoprim/Sulfamethoxazole for Pneumocystis Jiroveci Pneumonia After Solid Organ Transplantation Population (CTSTOP)

Typeobservational_patient_registrySponsorShanghai Zhongshan HospitalRan2017 to 2019Enrolled30ConditionsPneumocystis Jirovecii Pneumonia, Solid Organ Transplantation
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Successful treatment of severeSAGE open medical case reports · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Zhun-Yong GuDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Wen-Jun LiuDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Dan-Lei HuangDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Yu-Jing LiuDepartment of Nursing, Zhongshan Hospital, Fudan University, Shanghai, China.
Hong-Yu HeDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Cheng YangDepartment of Urology Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yi-Mei LiuDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Ming XuDepartment of Urology Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Rui-Ming RongDepartment of Urology Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Du-Ming ZhuDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhe LuoDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Min-Jie JuDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Fudan University · CNSun Yat-sen University · CNThe First Affiliated Hospital, Sun Yat-sen University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Evaluate the effect of the combination of clindamycin with low-dose trimethoprim-sulfamethoxazole (TMP/SMX) regimen on sever Method: 20 severe PCP patients after renal transplantation were included in this historical-control, retrospective study. A 10 patients were treated with the standard dose of TMP/SMX (T group), the other 10 patients were treated with the combination of clindamycin and low dose TMP/SMX (CT group). Results: Although there was no significant difference in the hospital survival between the two groups, the CT protocol improved the PaO2/FiO2 ratio more significantly and rapidly after the 6th ICU day (1.51 vs. 0.38, Conclusion: The current study proposed that clindamycin combined with low-dose TMP/SMX was more effective and safer the than single use of TMP/SMX for severe PCP patients after renal transplantation (NCT04328688).

Indexed as

clindamycincombinationPneumocystis pneumoniarenal transplantationtrimethoprim-sulfamethoxazole

Identifiers

PMID35602475
PMCPMC9120531
OpenAlexW4229058350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.