ArticleCommunications medicine2021
An analysis of frailty and multimorbidity in 20,566 UK Biobank participants with type 2 diabetes.
Article in Communications medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Age and Sex Differences in Efficacy of Treatments for Type 2 Diabetes: A Network Meta-Analysis.JAMA · 2025Pooled it
- Orthopedic frailty risk stratification (OFRS): a systematic review of the frailty indices predicting adverse outcomes in orthopedics.Journal of orthopaedic surgery and research · 2025Pooled it
- Comorbidity and health-related quality of life in people with a chronic medical condition in randomised clinical trials: An individual participant data meta-analysis.PLoS medicine · 2023Pooled it
- Trial
- Age-dependent health risks of smoking: greater harm associated with initiation before alveolar maturation (age 24).Journal of global health · 2026Article
- Poor sleep is robustly correlated with accelerated aging but the evidence for causation is mixed.medRxiv : the preprint server for health sciences · 2026Article
- Sugar rationing in the first 1000 days of life and risk of frailty: evidence from a natural experiment.The journal of nutrition, health & aging · 2026Article
- Article
- Frailty and Cardiovascular Events as Determined by Body Composition: A Systematic Review.Chronic diseases and translational medicine · 2026Review
- Multi-dimensional risk prediction and genetic architecture of aspiration pneumonia: a population-based analysis.BMC infectious diseases · 2026Article
- Frailty and multimorbidity among adults aged 40-69 years in Montenegro: a cross-sectional pilot study.BMJ open · 2025Article
- Practical Considerations in the Management of Frail Older People with Diabetes.Diseases (Basel, Switzerland) · 2025Review
- Frailty in Adults with CKD and Validation of the Kidney Failure Risk Equation in Frailty Subgroups.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Article
- The mediating and joint effects of depression in the association between cardiovascular health and frailty in middle-aged and elderly people: evidence from NHANES.Frontiers in psychiatry · 2025Article
- Individualized treatment of diabetes mellitus in older adults.Geriatrics & gerontology international · 2024Review
- Trajectories and management of vascular risk following the diagnosis of multiple sclerosis: A population-based matched cohort study between 1987 and 2018 in England.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
- Management of older adults with diabetes mellitus: Perspective from geriatric medicine.Journal of diabetes investigation · 2024Review
- Frailty Detection in Older Adults with Diabetes: A Scoping Review of Assessment Tools and Their Link to Key Clinical Outcomes.Journal of clinical medicine · 2024Article
- Regional differences in frailty among older adults with type 2 diabetes: a multicenter cross-sectional study in Japan.BMC geriatrics · 2024Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Background: Frailty and multimorbidity are common in type 2 diabetes (T2D), including people <65 years. Guidelines recommend adjustment of treatment targets in people with frailty or multimorbidity. It is unclear how recommendations to adjust treatment targets in people with frailty or multimorbidity should be applied to different ages. We assess implications of frailty/multimorbidity in middle/older-aged people with T2D. Methods: We analysed UK Biobank participants ( Results: Here we show that choice of measure influences the population identified: 42% of participants are frail or multimorbid by at least one measure; 2.2% by all four measures. Each measure is associated with mortality, MACE, hypoglycaemia, and fall or fracture. The absolute 5-year mortality risk is higher in older versus younger participants with a given level of frailty (e.g. 1.9%, and 9.9% in men aged 45 and 65, respectively, using frailty phenotype) or multimorbidity (e.g. 1.3%, and 7.8% in men with 4 LTCs aged 45 and 65, respectively). Using frailty phenotype, the relationship between higher HbA1c and mortality is stronger in frail compared with pre-frail or robust participants. Conclusions: Assessment of frailty/multimorbidity should be embedded within routine management of middle-aged and older people with T2D. Method of identification as well as features such as age impact baseline risk and should influence clinical decisions (e.g. glycaemic control).
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Registered trials
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