Evidence map›Paper›PMID 35602135›Full record

SynthesisFrontiers in public health2022

Alcohol and Health Outcomes: An Umbrella Review of Meta-Analyses Base on Prospective Cohort Studies.

Lixian Zhong, Weiwei Chen, Tonghua Wang, Qiuting Zeng, Leizhen Lai, Junlong Lai, Junqin Lin, Shaohui Tang

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Alcohol Consumption Behaviors and Liver Disease: Is There a Safer Drinking Practices?Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Binge drinking in Brazil during the COVID-19 pandemic: why does gender still matter?Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lixian ZhongDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Weiwei ChenDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Tonghua WangDepartment of Gastroenterology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Qiuting ZengDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Leizhen LaiDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Junlong LaiDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Junqin LinDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Shaohui TangDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An umbrella review of meta-analyses was performed to summarize the evidence of associations between alcohol consumption and health outcomes and to assess its credibility. Meta-analyses of prospective cohort studies reporting the associations of alcohol consumption with health outcomes were identified. We recalculated the random-effects summary effect size and 95% confidence interval, heterogeneity, and small-study effect for each meta-analysis and graded the evidence. Fifty-nine publications reporting 224 meta-analyses of prospective cohort studies with 140 unique health outcomes were included, in which there were 49 beneficial associations and 25 harmful associations with nominally statistically significant summary results. But quality of evidence was rated high only for seven beneficial associations (renal cell carcinoma risk, dementia risk, colorectal cancer mortality, and all-cause mortality in patients with hypertension for low alcohol consumption; renal cell carcinoma risk, cardiovascular disease (CVD) risk in patients with hypertension and all-cause mortality in patients with hypertension for moderate consumption) and four harmful associations (cutaneous basal cell carcinoma risk for low alcohol consumption; cutaneous basal cell carcinoma risk and cutaneous squamous cell carcinoma risk for moderate alcohol consumption; hemorrhagic stroke risk for high alcohol consumption). In this umbrella review, only 11 health outcomes (5 in low alcohol consumption, 5 in moderate alcohol consumption and 1 in high alcohol consumption) with statistically significant showed high quality of epidemiologic evidence. More robust and larger prospective studies are needed to verify our results.

Indexed as

Alcohol DrinkingDiseaseHumansMeta-Analysis as TopicMortalityOutcome Assessment, Health CareProspective Studiesalcoholepidemiologic evidencehealth outcomesmeta-analysisumbrella review

Identifiers

PMID35602135
PMCPMC9115901

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.