Evidence map›Paper›PMID 35602099›Full record

ArticleOxidative medicine and cellular longevity2022

Wheel-Running Exercise Protects Ovariectomized Mice from Bone Loss via IFN-

Hao Shen, Jiaheng He, Xuwei Ling, Chang Liu, Yi Wang, Xiongjinfu Zhang, Xu He, Huilin Yang, Mimi Chen, Qin Shi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. The role of CD8Frontiers in immunology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Hao ShenDepartment of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedics Institute of Soochow University, Medical College of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China.
Jiaheng HeDepartment of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedics Institute of Soochow University, Medical College of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China.
Xuwei LingDepartment of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedics Institute of Soochow University, Medical College of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China.
Chang LiuDepartment of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedics Institute of Soochow University, Medical College of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China.
Yi WangDepartment of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedics Institute of Soochow University, Medical College of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China.
Xiongjinfu ZhangDepartment of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedics Institute of Soochow University, Medical College of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China.
Xu HeDepartment of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedics Institute of Soochow University, Medical College of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China.
Huilin YangDepartment of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedics Institute of Soochow University, Medical College of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China.ORCID https://orcid.org/0000-0002-9459-7981
Mimi ChenDepartment of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedics Institute of Soochow University, Medical College of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China.ORCID https://orcid.org/0000-0003-1337-3570
Qin ShiDepartment of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedics Institute of Soochow University, Medical College of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China.ORCID https://orcid.org/0000-0002-9403-752X
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical exercise is recommended as a preventative approach for osteoporosis; however, the effect of physical exercise on bone mass remains controversial. Additionally, the immune regulation of physical exercise on bone mass remains unclear. To determine whether wheel-running (WR) exercise contributes to improving bone mineral density (BMD) and investigate the involved immune mechanism, ovariectomized (OVX) and sham-operated mice were treated with 8 weeks of WR exercise. The distal femurs of the mice were sequentially scanned, reconstructed, and analyzed using microcomputed tomography and related software to assess BMD and bone microarchitecture. Flow cytometry assays were applied to investigate alterations in immune cells and inflammatory cytokines.

Indexed as

Bone Diseases, MetabolicNF-kappa BPhysical Conditioning, AnimalAnimalsBone DensityCD8-Positive T-LymphocytesFemaleMAP Kinase Signaling SystemMiceOvariectomyX-Ray MicrotomographyNF-kappa B

Identifiers

PMID35602099
PMCPMC9117016
OpenAlexW4280620507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.