ArticleFrontiers in microbiology2022
Optimal NaCl Medium Enhances Squalene Accumulation in
Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Anticancer, Antitumor, and Antioxidant Microbial Lipids: Mechanism of Action, Production, and Clinical Application.Oxidative medicine and cellular longevity · 2026Review
- Production of squalene and fatty acids by Thraustochytrium sp. RT2316-16: effects of dissolved oxygen and the medium composition.Bioresources and bioprocessing · 2025Article
- Salinity Modulates Carbon Flux to Promote Squalene and PUFA Biosynthesis in the Marine ProtistMarine drugs · 2025Article
- Machine learning-led semi-automated medium optimization reveals salt as key for flaviolin production in Pseudomonas putida.Communications biology · 2025Article
- Optimization of Squalene Production byMolecules (Basel, Switzerland) · 2025Article
- Squalene production under oxygen limitation by Schizochytrium sp. S31 in different cultivation systems.Applied microbiology and biotechnology · 2024Article
- Bioprocess conditions and regulation factors to optimize squalene production in thraustochytrids.World journal of microbiology & biotechnology · 2023Review
- Alpha-Tocopherol Significantly Improved Squalene Production Yield ofAntioxidants (Basel, Switzerland) · 2023Article
- Article
- Spermatophore development in drones indicates the metabolite support for sperm storage in honey bees (Frontiers in physiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Squalene, a natural lipid of the terpenoid family, is well-recognized for its roles in regulating cholesterol metabolism, preventing tumor development, and improving immunity. For large-scale squalene production, the unicellular marine protists-thraustochytrids-have shown great potential. However, the growth of thraustochytrids is known to be affected by salt stress, which can eventually influence the squalene content. Here, we study the effects of an optimal concentration of NaCl on the squalene content and transcriptome of
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Registered trials
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