Evidence map›Paper›PMID 35601992›Full record

ArticleResearch in autism spectrum disorders2022

Increased Intra-Subject Variability of Neural Activity During Speech Production in People with Autism Spectrum Disorder.

Elizabeth S Heller Murray, Jennifer Segawa, F Isik Karahanoglu, Catherine Tocci, Jason A Tourville, Alfonso Nieto-Castanon, Helen Tager-Flusberg, Dara S Manoach, Frank H Guenther

Open access · greenAbstract read
In one paragraph

Article in Research in autism spectrum disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Oromotor skills in autism spectrum disorder: A scoping review.Autism research : official journal of the International Society for Autism Research · 2023
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Elizabeth S Heller MurrayBoston University, Department of Speech, Language, & Hearing Sciences, 635 Commonwealth Avenue, Boston, MA, 02215.
Jennifer SegawaBoston University, Department of Speech, Language, & Hearing Sciences, 635 Commonwealth Avenue, Boston, MA, 02215.
F Isik KarahanogluMassachusetts General Hospital, Department of Psychiatry, Harvard Medical School, 55 Fruit Street, Boston, MA, 02215.
Catherine TocciMassachusetts General Hospital, Department of Psychiatry, Harvard Medical School, 55 Fruit Street, Boston, MA, 02215.
Jason A TourvilleBoston University, Department of Speech, Language, & Hearing Sciences, 635 Commonwealth Avenue, Boston, MA, 02215.
Alfonso Nieto-CastanonBoston University, Department of Speech, Language, & Hearing Sciences, 635 Commonwealth Avenue, Boston, MA, 02215.
Helen Tager-FlusbergBoston University, Department of Psychological and Brain Sciences, 64 Cummington Mall Boston, MA, 02115.
Dara S ManoachMassachusetts General Hospital, Department of Psychiatry, Harvard Medical School, 55 Fruit Street, Boston, MA, 02215.
Frank H GuentherBoston University, Department of Speech, Language, & Hearing Sciences, 635 Commonwealth Avenue, Boston, MA, 02215.
Boston University · USMassachusetts General Hospital · US

Funding

Testing the efficacy of a novel intervention for minimally verbal children with P50DC013027 · NIDCD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI SHINN-CUNNINGHAM, BARBARA · 2012 to 2016
$9.4M
Sequencing and Initiation in Speech ProductionR01DC007683 · NIDCD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI FRANK H GUENTHER · 2006 to 2026
$9.0M
NEURAL MODELING AND IMAGING OF SPEECHR01DC002852 · NIDCD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI GUENTHER, FRANK H · 2001 to 2020
$7.2M
Advanced Research Training in Communication Sciences and DisordersT32DC013017 · NIDCD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Cara E. Stepp · 2016 to 2026
$4.9M
NIDCD NIH HHS P50 DC013027NIDCD NIH HHS R01 DC002852NIDCD NIH HHS R01 DC007683NIDCD NIH HHS T32 DC013017
6 · The paper itself

Abstract

Background: Communication difficulties are a core deficit in many people with autism spectrum disorder (ASD). The current study evaluated neural activation in participants with ASD and neurotypical (NT) controls during a speech production task. Methods: Neural activities of participants with ASD (N = 15, Results: There were no differences between the ASD and NT groups in average speech activation or inter-subject run-to-run variability in speech activation. Intra-subject run-to-run neural variability was greater in the ASD group and was positively correlated with autism severity in cortical areas associated with speech. Conclusions: These findings highlight the importance of understanding intra-subject neural variability in participants with ASD.

Indexed as

communicationfunctional magnetic resonance imagingspeechvariability

Identifiers

PMID35601992
PMCPMC9119427
OpenAlexW4226287254

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.