Evidence map›Paper›PMID 35601911›Full record

SynthesisFrontiers in human neuroscience2022

Safety and Efficacy of Cell Transplantation on Improving Motor Symptoms in Patients With Parkinson's Disease: A Meta-Analysis.

Jiaming Wang, Yu Tian, Xin Shi, Zhaohai Feng, Lei Jiang, Yujun Hao

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiaming WangDepartment of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China.
Yu TianDepartment of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China.
Xin ShiDepartment of Neurosurgery, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy Centre, Shenzhen University, Shenzhen, China.
Zhaohai FengDepartment of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China.
Lei JiangDepartment of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China.
Yujun HaoDepartment of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The past four decades have seen the growing use of tissue or cell transplants in Parkinson's disease (PD) treatment. Parkinson's cell therapy is a promising new treatment; however, efficacy of cell transplantation for Parkinson's disease are entirely unclear. Objective: To conduct a meta-analysis and a systematic review of the efficacy of cell therapy in patients with PD. Methods: A systematic literature review and meta-analysis of 10 studies were performed to assess the efficacy of cell therapy in Parkinson's patients. To achieve this, we compared the change in Unified Parkinson's Disease Rating Scale (UPDRS) II and III scale scores to baseline and assessed the incidence of transplant-related adverse events. The MINORS score and the I Results: The literature search yielded 10 articles ( Conclusion: The present findings demonstrate important clues on the therapeutic effect of cell therapy in alleviating motor impairment and daily living ability in PD patients.

Indexed as

cell transplantationmeta-analysismotorParkinson’s diseasestem cells

Identifiers

PMID35601911
PMCPMC9120834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.