ArticleClinical and translational radiation oncology2022
Proton therapy of a pregnant patient with nasopharyngeal carcinoma.
Article in Clinical and translational radiation oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Pregnancy, cancer, and radiation-a modern refresher.JNCI cancer spectrum · 2026Guideline
- A case report of radiotherapy for head and neck cancer in a pregnant woman: dosimetric optimization andTechnical innovations & patient support in radiation oncology · 2026Article
- Case Report: Proton Therapy of a Pregnant Patient With Small-Cell Lung Cancer in the Third Trimester Using Synthetic Computed Tomographies for Tumor Monitoring.Advances in radiation oncology · 2026Article
- Pediatric Nasopharyngeal Carcinoma (NPC).Current oncology reports · 2026Review
- Advanced stage melanoma during pregnancy: recommendations from a retrospective, multicentre, registry-based study.EClinicalMedicine · 2025Article
- Out-of-field dose assessment for pencil beam scanning proton radiotherapy versus photon radiotherapy for breast cancer in pregnant women.Physics and imaging in radiation oncology · 2025Article
- Treatment of a Pregnant Patient With a Brain Tumor Using Pencil Beam Scanning Proton Therapy.Advances in radiation oncology · 2025Article
- Fetal dose assessment in a pregnant patient with brain tumor: A comparative study of proton PBS and 3DCRT/VMAT radiation therapy techniques.Journal of applied clinical medical physics · 2024Article
- Results of an international survey on the current organization of care for pregnant women with cancer.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Challenges and opportunities for proton therapy during pregnancy.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Measurements of fetal dose with Mevion S250i proton therapy system with HYPERSCAN.Journal of applied clinical medical physics · 2023Article
- Cancer in pregnancy: treatment effects.Abdominal radiology (New York) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: Radiotherapy during pregnancy is rarely administered due to lack of data and practical challenges. This is the first detailed report of proton therapy as cancer treatment for a pregnant patient with nasopharyngeal carcinoma. Materials and methods: Pencil beam scanning proton therapy was prescribed to a pregnant patient to a total dose of 70 Gy (RBE) to the therapeutic CTV and 54.25 Gy to the prophylactic CTV, delivered in 35 fractions with a simultaneous integrated boost technique. Results: Phantom measurements showed a thirty-fold decrease in fetal radiation dose when using proton compared to photon therapy, with a total fetal dose of 5.5 mSv for the complete proton treatment, compared to 185 and 298 mSv for the photon treatment with and without lead shielding, respectively. After adminstering proton therapy during pregnancy, at 39 weeks of gestation, a healthy boy with a birthweight on the 83th percentile was delivered. Pediatric follow-up at 2 months of age of the offspring showed normal growth and age-adequate motor development with no signs of neurological problems. MR follow-up of the tumor 3 months after the end of treatment showed complete remission. Conclusion: This case demonstrates the potential of proton therapy for treatment during pregnancy.Compared to photon therapy, proton therapy can significantly limit fetal dose, while simultaneously offering a more optimized treatment to the patient.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.