ArticleMacromolecules2021
High-Throughput FRAP Analysis of Solute Diffusion in Hydrogels.
Article in Macromolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Post-fabrication reconfiguration of hydrogels through thermodynamic asymmetry in dynamic chemistry.Nature communications · 2026Article
- Microglia encapsulation in nanozyme-loaded hydrogels: response to oxidative stress and inflammation.Nanomedicine (London, England) · 2026Article
- Cascade-Responsive MXene@Cu-MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Intersecting Physical Mechanisms That Regulate Cell Viability in 3D Synthetic Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Food-Grade Emulsion Gels as Nutrient Delivery Systems-Standardized Workflow for Fabrication, Characterization, and Application.Gels (Basel, Switzerland) · 2026Review
- Dynamics of the formation of flat clathrin lattices in response to growth factor stimulus.PLoS computational biology · 2026Article
- Using High-Throughput Screening to Identify Crosslinking Peptides That Control Cell-Mediated Matrix Degradation.Advanced healthcare materials · 2025Article
- Establishing a 3D Vascularized Tri-Culture Model of the Human Airways via a Digital Light Processing Bioprinter.Biotechnology and bioengineering · 2025Article
- Rapid and Inexpensive Image-Guided Grayscale Biomaterial Customization via LCD Printing.Journal of biomedical materials research. Part A · 2025Article
- A Simple Method to Determine Diffusion Coefficients in Soft Hydrogels for Drug Delivery and Biomedical Applications.ACS omega · 2025Article
- Nanomachine Networks: Functional All-Enzyme Hydrogels from Photochemical Cross-Linking of Glucose Oxidase.Biomacromolecules · 2025Article
- Photochemical Control of Network Topology in PEG Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Near-infrared light-responsive hydrogels for on-demand dual delivery of proangiogenic growth factors.Acta biomaterialia · 2024Article
- Outlook and opportunities for engineered environments of breast cancer dormancy.Science advances · 2024Review
- Structurally decoupled stiffness and solute transport in multi-arm poly(ethylene glycol) hydrogels.Biomaterials · 2023Article
- Single versus dual microgel species for forming guest-host microporous annealed particle PEG-MAL hydrogel.Journal of biomedical materials research. Part A · 2023Article
- Lecithin as an Effective Modifier of the Transport Properties of Variously Crosslinked Hydrogels.Gels (Basel, Switzerland) · 2023Article
- Optimization of Media Change Intervals through Hydrogels Using Mathematical Models.Biomacromolecules · 2023Article
- Recent advances in regenerative biomaterials.Regenerative biomaterials · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Increasingly accurate mathematical models have been developed to relate solute and hydrogel properties to solute diffusion coefficients in hydrogels, primarily by comparing solute sizes and hydrogel mesh sizes. Here, we use a standardized, high-throughput method for fluorescence recovery after photobleaching (FRAP) experiments and analysis to characterize the diffusion coefficients of fluorescein, three sizes of FITC-dextran, and three sizes of FITC-conjugated poly(ethylene glycol) (PEG) through 18 structurally varied poly(vinyl alcohol) (PVA) hydrogel formulations. Increasing the hydrogel mesh radii increased the diffusivities of all the tested solutes within the hydrogels. While the diffusivity of FITC-dextrans in hydrogels decreased with increasing solute size, the diffusivity of FITC-PEGs increased with increasing solute size, suggesting that a generalized hydrodynamic radius-based model is not universally applicable for solute diffusion in hydrogels. The high-throughput characterization method for solute diffusion in hydrogels described here facilitates precise hydrogel design for biomedical applications.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.