Evidence map›Paper›PMID 35601692›Full record

ArticleIBRO neuroscience reports2022

Co-transmitting neurons in the lateral septal nucleus exhibit features of neurotransmitter switching.

Patrick J Hunt, Mikhail Kochukov, Brandon T Pekarek, Benjamin D W Belfort, Juan M Romero, Jessica L Swanson, Benjamin R Arenkiel

Open access · goldAbstract read
In one paragraph

Article in IBRO neuroscience reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Patrick J HuntGenetics and Genomics Program, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, USA.
Mikhail KochukovDepartment of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, USA.
Brandon T PekarekGenetics and Genomics Program, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, USA.
Benjamin D W BelfortGenetics and Genomics Program, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, USA.
Juan M RomeroMedical Scientist Training Program, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, USA.
Jessica L SwansonGenetics and Genomics Program, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, USA.
Benjamin R ArenkielDepartment of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, USA.
Texas Children's Hospital · USNeurological Research Institute · USBaylor College of Medicine · USBaylor Genetics · US

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
R01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.R01DK109934 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, Qingchun Tong · 2016 to 2026
$5.4M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2M
MAPPING CONNECTIVITY ONTO POSTNATAL-BORN NEURONSR01NS078294 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ARENKIEL, BENJAMIN R · 2012 to 2023
$3.6M
NICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NICHD NIH HHS U54 HD090255NIDDK NIH HHS R01 DK109934NINDS NIH HHS R01 NS078294
6 · The paper itself

Abstract

The lateral septal nucleus (LSN) is a highly interconnected region of the central brain whose activity regulates widespread circuitry. As such, the mechanisms that govern neuronal activity within the LSN have far-reaching implications on numerous brain-wide nuclei, circuits, and behaviors. We found that GABAergic neurons within the LSN express markers that mediate the release of acetylcholine (ACh). Moreover, we show that these vGAT

Indexed as

AcetylcholineCo-transmissionGABALateral Septal NucleusNeurotransmitterNeurotransmitter switching

Identifiers

PMID35601692
PMCPMC9121281
OpenAlexW4280619701

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.