Evidence map›Paper›PMID 35601066›Full record

ArticleExperimental and therapeutic medicine2022

PAX2 induces vascular-like structures in normal ovarian cells and ovarian cancer.

Kholoud Alwosaibai, Ensaf M Al-Hujaily, Salmah Alamri, Salim Ghandorah, Kenneth Garson, Barbara C Vanderhyden

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. International journal of molecular sciences · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kholoud AlwosaibaiBiomedical Research Department, Research Center, King Fahad Specialist Hospital, Dammam 32253, Saudi Arabia.
Ensaf M Al-HujailyDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Salmah AlamriBiomedical Research Department, Research Center, King Fahad Specialist Hospital, Dammam 32253, Saudi Arabia.
Salim GhandorahDepartment of Pathology and Laboratory Medicine, King Fahad Specialist Hospital, Dammam 32253, Saudi Arabia.
Kenneth GarsonDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Barbara C VanderhydenDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In adult tissue, the paired box 2 (PAX2) protein is expressed in healthy oviductal, but not normal ovarian surface epithelial cells. PAX2 is expressed in a subset of cases of serous ovarian carcinoma; however, the role of PAX2 in the initiation and progression of ovarian cancer remains unknown. The aim of the present study was to determine the biological effects of PAX2 expression in normal and cancerous epithelial cells. By culturing the normal and cancerous ovarian cells that express PAX2 in 3D culture and staining the cells with vasculogenic mimicry markers such as CD31 and PAS, it was shown that PAX2 overexpression in both normal and cancerous ovarian epithelial cells induced formation of vascular-like structures both

Indexed as

angiogenesisCD31ovarian cancerpaired box 2periodic acid-Schifftubular channelvascular channelvasculogenic mimicry

Identifiers

PMID35601066
PMCPMC9117948

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.