Evidence map›Paper›PMID 35600836›Full record

ReviewThe World Allergy Organization journal2022

WAO-ARIA consensus on chronic cough - Part III: Management strategies in primary and cough-specialty care.

Philip W Rouadi, Samar A Idriss, Jean Bousquet, Tanya M Laidlaw, Cecilio R Azar, Mona S Al-Ahmad, Anahi Yañez, Maryam Ali Y Al-Nesf, Talal M Nsouli, Sami L Bahna and 31 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The World Allergy Organization journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. WAO - ARIA consensus on chronic cough: Executive summary.The World Allergy Organization journal · 2025
    Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 20 institutions in 22 countries.

Philip W RouadiDepartment of Otolaryngology - Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon.
Samar A IdrissDepartment of Otolaryngology - Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon.
Jean BousquetHospital Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Tanya M LaidlawDepartment of Medicine, Harvard Medical School, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital Boston, Massachusetts, USA.
Cecilio R AzarDepartment of Gastroenterology, American University of Beirut Medical Center (AUBMC), Beirut, Lebanon.
Mona S Al-AhmadDepartment of Microbiology, Faculty of Medicine, Kuwait University, Kuwait.
Anahi YañezINAER - Investigaciones en Alergia y Enfermedades Respiratorias, Buenos Aires, Argentina.
Maryam Ali Y Al-NesfAllergy and Immunology Section, Department of Medicine, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.
Talal M NsouliInternational Cough Institute, Washington, DC, USA.
Sami L BahnaAllergy & Immunology Section, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Eliane Abou-JaoudeInternational Cough Institute, Washington, DC, USA.
Fares H ZaitounDepartment of Allergy Otolaryngology, LAU-RIZK Medical Center, Beirut, Lebanon.
Usamah M HadiClinical Professor Department of Otolaryngology Head and Neck Surgery, American University of Beirut, Lebanon.
Peter W HellingsKU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Allergy and Clinical Immunology, Leuven, Belgium.
Glenis K ScaddingDepartment of ENT, RNENT Hospital, London, UK.
Peter K SmithClinical Medicine Griffith University, Southport Qld, 4215, Australia.
Mario Morais-AlmeidaAllergy Center, CUF Descobertas Hospital, Lisboa, Portugal.
René Maximiliano GómezSchool of Health Sciences, Catholic University of Salta, Argentina.
Sandra N Gonzalez DiazUniversidad Autónoma de Nuevo León, Hospital Universitario and Facultad de Medicina, Monterrey, Nuevo León, Mexico.
Ludger KlimekCenter for Rhinology and Allergology, Wiesbaden, Germany.
Georges S JuvelekianDepartment of Pulmonary, Critical Care and Sleep Medicine at Saint George Hospital University Medical Center, Beirut, Lebanon.
Moussa A RiachyDepartment of Pulmonary and Critical Care, Hôtel-Dieu de France university Hospital, Beirut, Lebanon.
Giorgio Walter CanonicaHumanitas University & Personalized Medicine Asthma & Allergy Clinic-Humanitas Research Hospital-IRCCS-Milano Italy.
David PedenUNC Center for Environmental Medicine, Asthma, and Lung Biology, Division of Allergy, Immunology and Rheumatology, Department of Pediatrics UNC School of Medicine, USA.
Gary W K WongDepartment of Pediatrics, Chinese University of Hong Kong, Hong Kong, China.
James SublettDepartment of Pediatrics, Section of Allergy and Immunology, University of Louisville School of Medicine, 9800 Shelbyville Rd, Louisville, KY, USA.
Jonathan A BernsteinUniversity of Cincinnati College of Medicine, Department of Internal Medicine, Division of Immunology/Allergy Section, Cincinnati, OH, USA.
Lianglu WangDepartment of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, 100730, China.
Luciana K TannoUniversité Montpellier, Montpellier, France.
Manana ChikhladzeMedical Faculty at Akaki Tsereteli State University, National Institute of Allergy, Asthma & Clinical Immunology, KuTaisi, Tskaltubo, Georgia.
Michael LevinDivision of Paediatric Allergology, Department of Paediatrics, University of Cape Town, South Africa.
Yoon-Seok ChangDivision of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea.
Bryan L MartinDepartment of Otolaryngology, Division of Allergy & Immunology, The Ohio State University, Columbus, OH, USA.
Luis CaraballoInstitute for Immunological Research, University of Cartagena. Cartagena de Indias, Colombia.
Adnan CustovicNational Heart and Lund Institute, Imperial College London, UK.
Jose Antonio Ortego-MartellHealth Science Institute, Autonomous University of Hidalgo, México.
Olivia J Ly LesslarLifeSpan Medicine, Santa Monica, LA, USA.
Erika Jensen-JarolimInstitute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna, Austria.
Motohiro EbisawaClinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan.
Alessandro FiocchiTranslational Pediatric Research Area, Allergic Diseases Research Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Holy See.
Ignacio J AnsoteguiDepartment of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain.
Administración Nacional de Laboratorios e Institutos de Salud · ARAkaki Tsereteli State University · GEAmerican University of Beirut · LBAmerican University of Beirut Medical Center · LBAmsterdam UMC Location University of Amsterdam · NLBambino Gesù Children's Hospital · ITBrigham and Women's Hospital · USCenter for Environmental Health · USChinese Academy of Medical Sciences & Peking Union Medical College · CNChinese University of Hong Kong · HKGriffith University · AUHamad Medical Corporation · QAHôpital Edouard Herriot · FRHospital Quirónsalud Barcelona · ESHôtel-Dieu de France · LBHumanitas University · ITHumboldt-Universität zu Berlin · DEImperial College London · GBKuwait University · KWLifespan · US

Funding

Medical Research Council MR/K002449/1Medical Research Council MR/K002449/2Medical Research Council MR/S002359/1Medical Research Council MR/S025340/1Medical Research Council MR/T031565/1Medical Research Council MR/W028352/1
6 · The paper itself

Abstract

Background: Chronic cough management necessitates a clear integrated care pathway approach. Primary care physicians initially encounter the majority of chronic cough patients, yet their role in proper management can prove challenging due to limited access to advanced diagnostic testing. A multidisciplinary approach involving otolaryngologists and chest physicians, allergists, and gastroenterologists, among others, is central to the optimal diagnosis and treatment of conditions which underly or worsen cough. These include infectious and inflammatory, upper and lower airway pathologies, or gastro-esophageal reflux. Despite the wide armamentarium of ancillary testing conducted in cough multidisciplinary care, such management can improve cough but seldom resolves it completely. This can be due partly to the limited data on the role of tests (eg, spirometry, exhaled nitric oxide), as well as classical pharmacotherapy conducted in multidisciplinary specialties for chronic cough. Other important factors include presence of multiple concomitant cough trigger mechanisms and the central neuronal complexity of chronic cough. Subsequent management conducted by cough specialists aims at control of cough refractory to prior interventions and includes cough-specific behavioral counseling and pharmacotherapy with neuromodulators, among others. Preliminary data on the role of neuromodulators in a proof-of-concept manner are encouraging but lack strong evidence on efficacy and safety. Objectives: The World Allergy Organization (WAO)/Allergic Rhinitis and its Impact on Asthma (ARIA) Joint Committee on Chronic Cough reviewed the recent literature on management of chronic cough in primary, multidisciplinary, and cough-specialty care. Knowledge gaps in diagnostic testing, classical and neuromodulator pharmacotherapy, in addition to behavioral therapy of chronic cough were also analyzed. Outcomes: This third part of the WAO/ARIA consensus on chronic cough suggests a management algorithm of chronic cough in an integrated care pathway approach. Insights into the inherent limitations of multidisciplinary cough diagnostic testing, efficacy and safety of currently available antitussive pharmacotherapy, or the recently recognized behavioral therapy, can significantly improve the standards of care in patients with chronic cough.

Indexed as

Chronic cough managementCough primary careCough specialty careLower airway diseaseNeuromodulatorsReflux coughSpeech therapyUpper airway cough syndrome

Identifiers

PMID35600836
PMCPMC9117692
OpenAlexW4280574724

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.