ArticleJHEP reports : innovation in hepatology2022
Higher subcutaneous adipose tissue radiodensity is associated with increased mortality in patients with cirrhosis.
Article in JHEP reports : innovation in hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Effect of adipose-related parameters on mortality in patients with liver cirrhosis: a meta-analysis.Annals of medicine · 2025Pooled it
- Morphomics, Survival, and Metabolites in Patients With Metastatic Pancreatic Cancer.JAMA network open · 2024Trial
- Prognostic role of radiomics-based body composition analysis for the 1-year survival for hepatocellular carcinoma patients.Journal of cachexia, sarcopenia and muscle · 2023Trial
- Subcutaneous Fat Density Is an Independent Predictor of Adverse Outcomes and Shows Early Improvement After Liver Transplantation.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- Subcutaneous Adipose Tissue Attenuation Change on Chest CT Is Associated with Overall Survival After Allogeneic Hematopoietic Stem Cell Transplantation.Thoracic research and practice · 2026Article
- Variation in image-assessed abdominal adiposity and skeletal muscle and their associations with pathological characteristics in renal cell carcinoma.Cancer causes & control : CCC · 2026Article
- Automated CT-based visceral fat density predicts mortality regardless of visceral fat area.The British journal of radiology · 2026Article
- Reply to the Letter to the Editor: Enhancing sarcopenia understanding through integrated morphometric, functional, and multimodal assessments in patients undergoing Yttrium-90 radioembolization for liver cancer.European radiology · 2026Article
- Tumor-Derived Polyamines Initiate Fat Wasting in Cancer Cachexia.bioRxiv : the preprint server for biology · 2025Article
- Subcutaneous Adipose Tissue Radiation Attenuation Is Associated With Increased 1-Year Mortality in Polytrauma Patients.Journal of cachexia, sarcopenia and muscle · 2025Article
- Type II fibre atrophy and nuclear disruption in decompensated cirrhosis.JHEP reports : innovation in hepatology · 2025Article
- Article
- Association between higher intermuscular adipose tissue and decreased renal function in patients with systemic lupus erythematosus mediated by insulin resistance.Insights into imaging · 2024Article
- A model based on adipose and muscle-related indicators evaluated by CT images for predicting microvascular invasion in HCC patients.Biomarker research · 2023Article
- Body composition and short-term mortality in patients critically ill with acute-on-chronic liver failure.JHEP reports : innovation in hepatology · 2023Article
- Coexistence of muscle atrophy and high subcutaneous adipose tissue radiodensity predicts poor prognosis in hepatocellular carcinoma.Frontiers in nutrition · 2023Article
- Adipose tissue radiodensity and mortality among patients with nonmetastatic breast cancer.Clinical nutrition (Edinburgh, Scotland) · 2022Article
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Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background & Aims: Association between sarcopenia and mortality in cirrhosis is well recognised; however, little is known about the clinical implications of adipose tissue radiodensity, indicative of biological features. This study aimed to determine an association between high subcutaneous adipose tissue (SAT) radiodensity and survival, compare the prevalence of high SAT radiodensity between healthy population and patients with cirrhosis, and identify an association between computed tomography (CT)-measured SAT radiodensity and histological characteristics. Methods: Adult patients with cirrhosis (n = 786) and healthy donors (n = 129) with CT images taken as part of the liver transplant (LT) assessment were included. Abdominal SAT biopsies (1-2 g) were harvested from the incision site at the time of LT from 12 patients with cirrhosis. Results: The majority of patients were male (67%) with a mean model for end-stage liver disease (MELD) score of 15 ± 8. SAT radiodensity above -83 HU in females (sub-distribution hazard ratio [sHR] 1.84, 95% CI 1.20-2.85, Conclusion: High SAT radiodensity frequently presents and is associated with a higher mortality in cirrhosis. SAT morphological rearrangement in patients with high SAT radiodensity might indicate diminished lipid stores and alterations in tissue characteristics. Lay summary: Poor quality of subcutaneous adipose tissue (fat under the skin) is associated with higher mortality in patients with end-stage liver disease. Fat cells are smaller in patients with poor adipose tissue quality.
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