ArticleBioengineering & translational medicine2022
Development of a stem cell spheroid-laden patch with high retention at skin wound site.
Article in Bioengineering & translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Polynucleotide and Hyaluronic Acid Mixture for Skin Wound Dressing for Accelerated Wound Healing.Tissue engineering and regenerative medicine · 2025Article
- Advances of exosomes in diabetic wound healing.Burns & trauma · 2025Review
- Translational Challenges in Drug Therapy and Delivery Systems for Treating Chronic Lower Extremity Wounds.Pharmaceutics · 2024Review
- Cu(II)-baicalein enhance paracrine effect and regenerative function of stem cells in patients with diabetes.Bioactive materials · 2024Article
- Transplantation of Stem Cell Spheroid-Laden 3-Dimensional Patches with Bioadhesives for the Treatment of Myocardial Infarction.Biomaterials research · 2024Article
- The Application of Photobiomodulation and Stem Cells Seeded on the Scaffold Accelerates the Wound Healing Process in Mice.Journal of lasers in medical sciences · 2024Article
- Three-Dimensional Cell Culture System for Tendon Tissue Engineering.Tissue engineering and regenerative medicine · 2023Review
- The Effect of the Mechanical Properties of the 3D Printed Gelatin/Hyaluronic Acid Scaffolds on hMSCs Differentiation Towards Chondrogenesis.Tissue engineering and regenerative medicine · 2023Article
- Multifunctional 3D platforms for rapid hemostasis and wound healing: Structural and functional prospects at biointerfaces.International journal of bioprinting · 2023Article
- Development of a stem cell spheroid-laden patch with high retention at skin wound site.Bioengineering & translational medicine · 2022Article
- Effect of composite biodegradable biomaterials on wound healing in diabetes.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mesenchymal stem cells such as human adipose tissue-derived stem cells (hADSCs) have been used as a representative therapeutic agent for tissue regeneration because of their high proliferation and paracrine factor-secreting abilities. However, certain points regarding conventional ADSC delivery systems, such as low cell density, secreted cytokine levels, and cell viability, still need to be addressed for treating severe wounds. In this study, we developed a three-dimensional (3D) cavity-structured stem cell-laden system for overdense delivery of cells into severe wound sites. Our system includes a hydrophobic surface and cavities that can enhance the efficiency of cell delivery to the wound site. In particular, the cavities in the system facilitate hADSC spheroid formation, increasing therapeutic growth factor expression compared with 2D cultured cells. Our hADSC spheroid-loaded patch exhibited remarkably improved cell localization at the wound site and dramatic therapeutic efficacy compared to the conventional cell injection method. Taken together, the hADSC spheroid delivery system focused on cell delivery, and stem cell homing effect at the wound site showed a significantly enhanced wound healing effect. By overcoming the limitations of conventional cell delivery methods, our overdense cell delivery system can contribute to biomedical and clinical applications.
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