Evidence map›Paper›PMID 35600617›Full record

ArticleFrontiers in neuroscience2022

Neuronal Dysfunction Is Linked to the Famine-Associated Risk of Proliferative Retinopathy in Patients With Type 2 Diabetes.

Olena Fedotkina, Ruchi Jain, Rashmi B Prasad, Andrea Luk, Marta García-Ramírez, Türküler Özgümüs, Liubov Cherviakova, Nadiya Khalimon, Tetiana Svietleisha, Tetiana Buldenko and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 6 countries.

Olena FedotkinaDepartment of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway.
Ruchi JainDepartment of Clinical Sciences, Lund University Diabetes Center, Skane University Hospital, Malmö, Sweden.
Rashmi B PrasadDepartment of Clinical Sciences, Lund University Diabetes Center, Skane University Hospital, Malmö, Sweden.
Andrea LukPrince of Wales Hospital, Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Marta García-RamírezVall d'Hebron Research Institute and CIBERDEM, Barcelona, Spain.
Türküler ÖzgümüsDepartment of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway.
Liubov CherviakovaChernihiv Regional Hospital, Chernihiv, Ukraine.
Nadiya KhalimonCity Hospital No. 2, Chernihiv, Ukraine.
Tetiana SvietleishaCity Hospital No. 1, Chernihiv, Ukraine.
Tetiana BuldenkoDepartment of Health Care of Chernihiv Regional State Administration, Chernihiv, Ukraine.
Victor KravchenkoKomisarenko Institute of Endocrinology and Metabolism, Kyiv, Ukraine.
Deepak JainDepartment of Clinical Sciences, Lund University Diabetes Center, Skane University Hospital, Malmö, Sweden.
Allan VaagSteno Diabetes Center Copenhagen, Copenhagen, Denmark.
Juliana ChanPrince of Wales Hospital, Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Mykola D KhalangotKomisarenko Institute of Endocrinology and Metabolism, Kyiv, Ukraine.
Cristina HernándezVall d'Hebron Research Institute and CIBERDEM, Barcelona, Spain.
Peter M NilssonDepartment of Clinical Sciences, Lund University Diabetes Center, Skane University Hospital, Malmö, Sweden.
Rafael SimoVall d'Hebron Research Institute and CIBERDEM, Barcelona, Spain.
Isabella ArtnerDepartment of Clinical Sciences, Lund University Diabetes Center, Skane University Hospital, Malmö, Sweden.
Valeriya LyssenkoDepartment of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway.
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · ESLund University · SEUniversity of Bergen · NOChernihiv Polytechnic National University · UASkåne University Hospital · SEChinese University of Hong Kong · CNPrince of Wales Hospital · CNShupyk National Healthcare University of Ukraine · UASteno Diabetes Center · DKV.P. Komisarenko Institute of Endocrinology and Metabolism · UA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persons with type 2 diabetes born in the regions of famine exposures have disproportionally elevated risk of vision-threatening proliferative diabetic retinopathy (PDR) in adulthood. However, the underlying mechanisms are not known. In the present study, we aimed to investigate the plausible molecular factors underlying progression to PDR. To study the association of genetic variants with PDR under the intrauterine famine exposure, we analyzed single nucleotide polymorphisms (SNPs) that were previously reported to be associated with type 2 diabetes, glucose, and pharmacogenetics. Analyses were performed in the population from northern Ukraine with a history of exposure to the Great Ukrainian Holodomor famine [the Diagnostic Optimization and Treatment of Diabetes and its Complications in the Chernihiv Region (DOLCE study),

Indexed as

diabetic retinopathyfamineintrauterine exposureneurodegenerationneuronal function

Identifiers

PMID35600617
PMCPMC9119187
OpenAlexW4229040392

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.