Evidence map›Paper›PMID 35600609›Full record

ArticleFrontiers in neuroscience2022

Intraoperative Real-Time Near-Infrared Image-Guided Surgery to Identify Intracranial Meningiomas

Jun Muto, Yutaka Mine, Yuya Nishiyama, Kazuhiro Murayama, Seiji Yamada, Daijiro Kojima, Motoharu Hayakawa, Kazuhide Adachi, Mitsuhiro Hasegawa, John Y K Lee and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Obstacles and Trials in Treating Primary Brain Tumors.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Jun MutoDepartment of Neurosurgery, Fujita Health University, Toyoake, Japan.
Yutaka MineDepartment of Neurosurgery, Saiseikai Yokohamashi Tobu Hospital, Yokohama, Japan.
Yuya NishiyamaDepartment of Neurosurgery, Fujita Health University, Toyoake, Japan.
Kazuhiro MurayamaDepartment of Radiology, Fujita Health University, Toyoake, Japan.
Seiji YamadaDepartment of Pathology, Fujita Health University, Toyoake, Japan.
Daijiro KojimaDepartment of Neurosurgery, Fujita Health University, Toyoake, Japan.
Motoharu HayakawaDepartment of Neurosurgery, Fujita Health University, Toyoake, Japan.
Kazuhide AdachiDepartment of Neurosurgery, Fujita Health University, Toyoake, Japan.
Mitsuhiro HasegawaDepartment of Neurosurgery, Fujita Health University, Toyoake, Japan.
John Y K LeeDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States.
Yuichi HiroseDepartment of Neurosurgery, Fujita Health University, Toyoake, Japan.
Fujita Health University · JPUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meningiomas are a common pathology in the central nervous system requiring complete surgical resection. However, in cases of recurrence and post-irradiation, accurate identification of tumor remnants and a dural tail under bright light remains challenging. We aimed to perform real-time intraoperative visualization of the meningioma and dural tail using a delayed-window indocyanine green (ICG) technique with microscopy. Fifteen patients with intracranial meningioma received 0.5 mg/kg ICG a few hours before observation during the surgery. We used near-infrared (NIR) fluorescence to identify the tumor location. NIR fluorescence could visualize meningiomas in 12 out of 15 cases. Near-infrared visualization during the surgery ranged from 1 to 4 h after the administration of ICG. The mean signal-to-background ratio (SBR) of the intracranial meningioma in delayed-window ICG (DWIG) was 3.3 ± 2.6. The ratio of gadolinium-enhanced T1 tumor signal to the brain (T1BR) (2.5 ± 0.9) was significantly correlated with the tumor SBR (

Indexed as

enhanced permeability retentionfluorescenceintracranial meningiomametabolic navigationnear-infraredsecond window indocyanine green

Identifiers

PMID35600609
PMCPMC9114498
OpenAlexW4225405726

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.