Evidence map›Paper›PMID 35600595›Full record

ArticleFrontiers in endocrinology2022

Downregulation of LHCGR Attenuates COX-2 Expression and Induces Luteinized Unruptured Follicle Syndrome in Endometriosis.

Ting Geng, Yifan Sun, Lin Cheng, Yuming Cao, Ming Zhang, Zhidan Hong, Ling Ma, Yuanzhen Zhang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ting GengReproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yifan SunReproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Lin ChengReproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yuming CaoReproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Ming ZhangReproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Zhidan HongReproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Ling MaReproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yuanzhen ZhangReproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Zhongnan Hospital of Wuhan University · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An association between endometriosis and luteinized unruptured follicle syndrome (LUFs) has long been identified. Although inactivating mutation of luteinizing hormone/choriogonadotropin receptor (LHGCR) results in LUFs, whether LHCGR contributes to promoting LUFs in endometriosis remains elusive. To investigate the effect of LHCGR signaling in the development of endometriosis-associated LUFs and dissect the underlying mechanism

Indexed as

Cyclooxygenase 2EndometriosisReceptors, LHAnimalsChorionic GonadotropinDown-RegulationFemaleGene Expression RegulationHumansMiceChorionic GonadotropinCyclooxygenase 2LHCGR protein, mousePtgs2 protein, mouseReceptors, LHCOX-2endometriosisLHCGRluteinized unruptured follicle syndromeovulation

Identifiers

PMID35600595
PMCPMC9114297
OpenAlexW4225410863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.