Evidence map›Paper›PMID 35600589›Full record

ArticleFrontiers in endocrinology2022

Investigating the Impact of the TUITEK

Pen-Hua Su, Sumaira Malik, Amrit Jheeta, Yen-Fan Lin, Su-Huei Su, Ekaterina Koledova, Selina Graham

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. The TUITEKFrontiers in endocrinology · 2025
    Article
  2. Article
  3. Review
  4. Evaluating the TUITEKFrontiers in endocrinology · 2023
    Article
  5. Precision diagnostics in children.Cambridge prisms. Precision medicine · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Pen-Hua SuSchool of Medicine, Chung-Shan Medical University, Taichung City, Taiwan.
Sumaira MalikAtlantis Healthcare, London, United States.
Amrit JheetaAtlantis Healthcare, London, United States.
Yen-Fan LinMedical Affairs Department, Merck Ltd., Taiwan, An Affiliate of Merck KGaA, Darmstadt, Germany, Taipei City, Taiwan.
Su-Huei SuDepartment of Pediatrics and Genetics, Chung Shan Medical University Hospital, Taichung City, Taiwan.
Ekaterina KoledovaEmpowered Health, Global Medical Affairs Cardiometabolic and Endocrinology, Merck KGaA, Darmstadt, Germany.
Selina GrahamEmpowered Health, London, United Kingdom.
Merck (Germany) · DEChung Shan Medical University · TWChung Shan Medical University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Poor adherence to recombinant human growth hormone (r-hGH) treatment presents a significant barrier to achieving optimal growth outcomes. It is important to identify and address the treatment adherence-related needs of children prescribed r-hGH treatment, and develop new approaches to improve adherence. We aimed to measure the impact of the TUITEK Patients and Methods: The evaluation of the TUITEK Results: Between baseline and follow-up, the percentage of caregivers scoring as 'high risk' for emotional burden reduced by 37%; there was an improvement in confidence of self-administration by 57% and the percentage of caregivers scoring as 'high risk' for treatment-related anxiety reduced by 52%. At follow-up, all caregivers classified as 'high risk' within the disease and treatment coherence item at baseline moved into the 'low risk' category. Statistically significant changes in questionnaire scores between baseline and follow-up for disease and treatment understanding, emotional burden, self-administration, and treatment-related anxiety were also observed. Conclusion: These findings indicate that the TUITEK

Indexed as

Human Growth HormoneCaregiversChildGrowth DisordersHumansRecombinant ProteinsTaiwanHuman Growth HormoneRecombinant Proteinsadherencecaregiverinterventionrecombinant human growth hormone (r-hGH) treatmentshort stature

Identifiers

PMID35600589
PMCPMC9120661
OpenAlexW4229058852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.