ArticleFrontiers in cardiovascular medicine2022
Elevated Blood Urea Nitrogen to Serum Albumin Ratio Is an Adverse Prognostic Predictor for Patients Undergoing Cardiac Surgery.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Prognostic value of albumin-based indices for mortality after heart failure: a systematic review and meta-analysis.BMC cardiovascular disorders · 2024Pooled it
- The Association Between Systemic Inflammatory and Metabolic Indices and Early Adverse Clinical Outcomes in Adult Patients Admitted to the Post-anaesthesia Care Unit: A Retrospective Observational Study.Turkish journal of anaesthesiology and reanimation · 2026Article
- Association Between the Ratio of Blood Urea Nitrogen to Serum Albumin, All-Cause and Cardiovascular Mortality, and Cardiovascular Disease Risk in USA Adults: An Observational Cohort Analysis.Health science reports · 2026Article
- Early Use of Fentanyl Increases Risk of Delirium in Patients Transfer to the intensive Care Unit After Cardiac Surgery Immediately: A Target Trial Emulation.Journal of evidence-based medicine · 2026Article
- Prognostic value of blood urea nitrogen to albumin ratio in critically ill cirrhotic patients with ascites.Scientific reports · 2026Article
- Dynamic BUN patterns in the ICU: risk stratification and prognosis following cardiac surgery.Journal of cardiothoracic surgery · 2026Article
- Association of Prognostic Nutritional Index and New-Onset Atrial Fibrillation in Patients Undergoing Surgical Aortic Valve Replacement: A Silent Predictor in Perioperative Outcomes?Journal of clinical medicine · 2026Article
- Blood Urea Nitrogen to Albumin Ratio is Associated with Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Blood urea nitrogen to albumin ratio and 1-year mortality after hip fracture surgery in older adults: a retrospective cohort study.Frontiers in medicine · 2026Article
- Bridging the gap between biomarkers and bedside decisions: the prognostic value of the blood urea nitrogen-to-albumin ratio in sepsis-associated AKI.Frontiers in nutrition · 2026Article
- BUN-albumin ratio as a prognostic marker in decompensated heart failure with reduced ejection fraction.American heart journal plus : cardiology research and practice · 2026Article
- Preoperative Outcome Predictors in Aortic Valve Replacement: A Single-Center Retrospective Study.Journal of clinical medicine · 2025Article
- Prognostic Value of Blood Urea Nitrogen to Albumin Ratio in Elderly Critically Ill Patients with Acute Kidney Injury: A Retrospective Study.Medicina (Kaunas, Lithuania) · 2025Article
- Association between the blood urea nitrogen to serum albumin ratio and the risk of mortality in patients with chronic kidney disease: a cohort study.BMC nephrology · 2025Article
- Article
- Association of the blood urea nitrogen to serum albumin ratio and 28-day all-cause mortality in patients with cardiac arrest: a retrospective cohort study using the MIMIC-IV database.Frontiers in cardiovascular medicine · 2025Article
- The relationship between blood urea nitrogen to serum albumin ratio and cardiovascular diseases, cardiovascular mortality, and all-cause mortality in patients with diabetes mellitus.Frontiers in endocrinology · 2025Article
- Association Between Blood Urea Nitrogen to Serum Albumin Ratio and Mortality in Critically Ill Patients With Chronic Obstructive Pulmonary Disease: A Retrospective Study.International journal of chronic obstructive pulmonary disease · 2025Article
- Article
- Blood urea nitrogen to albumin ratio as predictor of mortality among acute pancreatitis patients in ICU: A retrospective cohort study.PloS one · 2025Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Elevated blood urea nitrogen (BUN) and reduced albumin have been prominently correlated with unfavorable outcomes in patients with cardiovascular diseases. However, whether combination BUN and albumin levels could predict the adverse outcomes of cardiac surgery patients remains to be confirmed. Here, we investigated the prognostic effect of the preoperative BUN to serum albumin ratio (BAR) in cardiac surgery patients. Methods: Data were obtained from the Medical Information Mart for Intensive Care (MIMIC) III and eICU databases and classified into a training cohort and validation cohort. The BAR (mg/g) was calculated by initial BUN (mg/dl)/serum albumin (g/dl). The primary outcome was in-hospital mortality. Secondary outcomes were 1-year mortality, prolonged length at intensive care unit, and duration of hospital stay. The associations of BAR with outcomes were explored by multivariate regression analysis and subgroup analyses. Then, C statistics were performed to assess the added prognostic impact of BAR beyond a baseline risk model. Results: Patients with in-hospital death had significantly higher levels of BAR. Multivariate regression analysis identified BAR, as a categorical or continuous variable, as an independent factor for adverse outcomes of cardiac surgery (all Conclusions: Increased preoperative BAR is a potent predictor of unfavorable outcomes in patients undergoing cardiac surgery.
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