ArticleNature catalysis2021
Deacylation-Aided C─H Alkylative Annulation through C─C Cleavage of Unstrained Ketones.
Article in Nature catalysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 75 citations in OpenAlex.
- Photoinduced deacylative epoxidation of ketone derivatives with allylic peroxides.Chemical science · 2026Article
- Cross-ketone deacylative coupling via oxidative SNature communications · 2026Article
- Couple-close: Unified approach to semisaturated cyclic scaffolds.Science (New York, N.Y.) · 2026Article
- An IntegratedACS catalysis · 2026Article
- n-doping of organic semiconductors catalysed by organometallic complexes.Nature communications · 2025Article
- Modular esterification of unstrained carbonyls through palladium-catalyzed alkyne bridging C-C bond activation.Nature communications · 2025Article
- Deacylative Polyfluoroarylation via C-C Cleavage of Alkyl Ketones.Organic letters · 2025Article
- Carbonyl-to-sulfur swap enabled by sequential double carbon-carbon bond activation.Science (New York, N.Y.) · 2025Article
- Photoinduced formal [4 + 2] cycloaddition of two electron-deficient olefins and its application to the synthesis of lucidumone.Nature communications · 2024Article
- Aromatization-driven deconstructive functionalization of spiro dihydroquinazolinonesChemical science · 2024Article
- Deacylative arylation and alkynylation of unstrained ketones.Science advances · 2024Article
- Methyl Ketones as Alkyl Halide Surrogates: A Deacylative Halogenation Approach for Strategic Functional Group Conversions.Journal of the American Chemical Society · 2023Article
- Deacylative Thiolation by Redox-Neutral Aromatization-Driven C-C Fragmentation of Ketones.Angewandte Chemie (International ed. in English) · 2023Article
- Rapid syntheses of N-fused heterocycles via acyl-transfer in heteroaryl ketones.Nature communications · 2022Article
- Site-Specific and Degree-Controlled Alkyl Deuteration via Cu-Catalyzed Redox-Neutral Deacylation.Journal of the American Chemical Society · 2022Article
- Olefination via Cu-Mediated Dehydroacylation of Unstrained Ketones.Journal of the American Chemical Society · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Arene- and heteroarene-fused rings are pervasive in biologically active molecules. Direct annulation between a C─H bond on the aromatic core and a tethered alkyl moiety provides a straightforward approach to access these scaffolds; however, such a strategy is often hampered by the need of special reactive groups and/or less compatible cyclization conditions. It would be synthetically appealing if a common native functional group can be used as a handle to enable a general C─H annulation with diverse aromatic rings. Here, we show a deacylative annulation strategy for preparing a large variety of aromatic-fused rings from linear simple ketone precursors. The reaction starts with homolytic cleavage of the ketone α C─C bond via a pre-aromatic intermediate, followed by a radical-mediated dehydrogenative cyclization. Using widely available ketones as the robust radical precursors, this deconstructive approach allows streamlined assembly of complex polycyclic structures with broad functional group tolerance.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.