Evidence map›Paper›PMID 35600205›Full record

ArticleSensors international2020

A rapid blood test to monitor immunity shift during pregnancy and potential application for animal health management.

Tianyu Zheng, Yasmine Moustafa, Caroline Finn, Sydney Scott, Christopher J Haase, Nathaly A Carpinelli, Johan S Osorio, Karl K McKinstry, Tara M Strutt, Qun Huo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Parturition in Mammals: Animal Models, Pain and Distress.Animals : an open access journal from MDPI · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Tianyu ZhengNano Discovery Inc., 1060 Woodcock Road Suite 131, Orlando, FL, 32803, USA.
Yasmine MoustafaDepartment of Chemistry and NanoScience Technology Center, University of Central Florida, 12424 Research Parkway Suite 400, Orlando, FL, 32826, USA.
Caroline FinnBurnett School of Biomedical Science, Division of Immunity and Pathogenesis, College of Medicine, University of Central Florida, 6900 Lake Nona Blvd., Orlando, FL, 32827, USA.
Sydney ScottDepartment of Chemistry and NanoScience Technology Center, University of Central Florida, 12424 Research Parkway Suite 400, Orlando, FL, 32826, USA.
Christopher J HaaseCJ Haase Veterinary & Immunological Service, 407 Prairie St, Reeseville, WI, 53579, USA.
Nathaly A CarpinelliDairy and Food Science Department, South Dakota State University, Brookings, SD, 57007, USA.
Johan S OsorioDairy and Food Science Department, South Dakota State University, Brookings, SD, 57007, USA.
Karl K McKinstryBurnett School of Biomedical Science, Division of Immunity and Pathogenesis, College of Medicine, University of Central Florida, 6900 Lake Nona Blvd., Orlando, FL, 32827, USA.
Tara M StruttBurnett School of Biomedical Science, Division of Immunity and Pathogenesis, College of Medicine, University of Central Florida, 6900 Lake Nona Blvd., Orlando, FL, 32827, USA.
Qun HuoDepartment of Chemistry and NanoScience Technology Center, University of Central Florida, 12424 Research Parkway Suite 400, Orlando, FL, 32826, USA.
University of Central Florida · USSouth Dakota State University · USDiscovery Semiconductors (United States) · US

Funding

Memory T cell protection of reproductive health following influenza infectionR21HD093948 · NICHD · UNIVERSITY OF CENTRAL FLORIDA · PI STRUTT, TARA MARLENE · 2018 to 2019
$410k
NICHD NIH HHS R21 HD093948
6 · The paper itself

Abstract

The immune health of a farm animal can have significant impact on its overall health, welfare and productivity. One of the most vulnerable physiological states for both humans and animals is pregnancy. Many systemic changes correlate with the gravid state, including shifts in the immune system that may impact the ability to respond optimally to pathogen challenge. Because of this, it would be beneficial to be able to monitor the immune health of the pregnant animals closely. Recently, we developed a new nanoparticle-enabled rapid blood test that can detect ongoing immune responses from both laboratory and farm animals. Here, we report that this novel test reveals highly repeatable and acute changes associated with pregnancy and peri-parturition period in laboratory mice and in cattle. We hypothesize that the test score change reflects changes in the immune status of the gravid females related to the humoral immune response. The test is easy to conduct, of low cost, with results obtained in less than 20 min. This rapid test could be potentially used as an onsite test in local farms and small clinics for animal health management.

Indexed as

Cattle reproductionImmune responseNanotechnologyPregnancy

Identifiers

PMID35600205
PMCPMC9122116
OpenAlexW3019312962

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.