Evidence map›Paper›PMID 35599981›Full record

ArticlePulmonary circulation2022

Pulmonary endothelial NEDD9 and the prothrombotic pathophenotype of acute respiratory distress syndrome due to SARS-CoV-2 infection.

George A Alba, Andriy O Samokhin, Rui-Sheng Wang, Bradley M Wertheim, Kathleen J Haley, Robert F Padera, Sara O Vargas, Ivan O Rosas, Lida P Hariri, Angela Shih and 3 more

Open access · goldAbstract read
In one paragraph

Article in Pulmonary circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

George A AlbaDivision of Pulmonary and Critical Care Medicine Massachusetts General Hospital Boston Massachusetts USA.ORCID https://orcid.org/0000-0002-6876-7836
Andriy O SamokhinDivision of Cardiovascular Medicine Brigham and Women's Hospital Boston Massachusetts USA.
Rui-Sheng WangDivision of Cardiovascular Medicine Brigham and Women's Hospital Boston Massachusetts USA.
Bradley M WertheimDivision of Pulmonary and Critical Care Medicine Brigham and Women's Hospital Boston Massachusetts USA.
Kathleen J HaleyDivision of Pulmonary and Critical Care Medicine Brigham and Women's Hospital Boston Massachusetts USA.
Robert F PaderaDepartment of Pathology Brigham and Women's Hospital Boston Massachusetts USA.
Sara O VargasDepartment of Pathology Boston Children's Hospital Boston Massachusetts USA.
Ivan O RosasDivision of Pulmonary and Critical Care Medicine Baylor College of Medicine Houston Texas USA.
Lida P HaririDivision of Pulmonary and Critical Care Medicine Massachusetts General Hospital Boston Massachusetts USA.
Angela ShihDepartment of Pathology Massachusetts General Hospital Boston Massachusetts USA.
Boyd Taylor ThompsonDivision of Pulmonary and Critical Care Medicine Massachusetts General Hospital Boston Massachusetts USA.
Richard N MitchellDepartment of Pathology Brigham and Women's Hospital Boston Massachusetts USA.
Bradley A MaronDivision of Cardiovascular Medicine Brigham and Women's Hospital Boston Massachusetts USA.
Brigham and Women's Hospital · USMassachusetts General Hospital · USBaylor College of Medicine · USBoston Children's Hospital · US

Funding

Boston Biomedical Innovation CenterU54HL119145 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLAN, DAVID E., LOSCALZO, JOSEPH · 2013 to 2021
$18.8M
Institutional Career Development CoreKL2TR002542 · NCATS · HARVARD MEDICAL SCHOOL · PI BREDELLA, MIRIAM ANTOINETTE, RUTKOVE, SEWARD B. · 2018 to 2022
$8.7M
Targeting FAK-NEDD9 protein-protein interaction to prevent focal adhesion assembly and vascular proliferation in pulmonary arterial hypertensionR01HL139613 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Sirano Dhe-Paganon, Bradley Maron · 2018 to 2026
$4.1M
NEDD9-SMAD3, fibrinolysis, and chronic thromboembolic pulmonary hypertensionR01HL153502 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI MARON, BRADLEY · 2020 to 2023
$1.7M
Personalized protein-protein interactomes and precision medicine in pulmonary arterial hypertensionR01HL155096 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI MARON, BRADLEY · 2021 to 2024
$1.6M
NCATS NIH HHS KL2 TR002542NHLBI NIH HHS R01 HL139613NHLBI NIH HHS R01 HL153502NHLBI NIH HHS R01 HL155096NHLBI NIH HHS U54 HL119145
6 · The paper itself

Abstract

The pathobiology of in situ pulmonary thrombosis in acute respiratory distress syndrome (ARDS) due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is incompletely characterized. In human pulmonary artery endothelial cells (HPAECs), hypoxia increases neural precursor cell expressed, developmentally downregulated 9 (NEDD9) and induces expression of a prothrombotic NEDD9 peptide (N9

Indexed as

acute respiratory distress syndromeendotheliumpulmonary biologySARS‐CoV‐2thrombosis

Identifiers

PMID35599981
PMCPMC9111030
OpenAlexW4225547324

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.