Evidence map›Paper›PMID 35599850›Full record

ArticleHGG advances2022

Stx4 is required to regulate cardiomyocyte Ca

Eliyahu Perl, Padmapriyadarshini Ravisankar, Manu E Beerens, Lejla Mulahasanovic, Kelly Smallwood, Marion Bermúdez Sasso, Carina Wenzel, Thomas D Ryan, Matej Komár, Kevin E Bove and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HGG advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Eliyahu PerlMedical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Padmapriyadarshini RavisankarDivision of Molecular Cardiovascular Biology, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Manu E BeerensCardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Lejla MulahasanovicPraxis für Humangenetik, Tübingen, Baden-Württemberg, Germany.
Kelly SmallwoodDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Marion Bermúdez SassoInstitute for Clinical Genetics, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Saxony, Germany.
Carina WenzelInstitute of Pathology, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
Thomas D RyanDepartment of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH, USA.
Matej KomárDepartment of Gynecology and Obstetrics, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Saxony, Germany.
Kevin E BoveDepartment of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH, USA.
Calum A MacRaeCardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
K Nicole WeaverDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Carlos E PradaDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Joshua S WaxmanDivision of Molecular Cardiovascular Biology, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Cincinnati Children's Hospital Medical Center · USUniversity Hospital Carl Gustav Carus · DEBrigham and Women's Hospital · USPraxis für Humangenetik Tübingen · DE

Funding

Molecular Mechanisms of Atrial Development and RegenerationR01HL137766 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Joshua Waxman · 2017 to 2026
$3.9M
Understanding Cardiovascular Disease MechanismsT32HL125204 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Evangelia G Kranias, Jeffery D Molkentin · 2015 to 2026
$3.4M
Mechanisms underlying myxomatous valve diseaseR01HL154522 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WAXMAN, JOSHUA · 2021 to 2024
$2.1M
Retinoic acid-dependent epigenetic and transcriptional mechanisms controlling heart developmentR01HL141186 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WAXMAN, JOSHUA · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL137766NHLBI NIH HHS R01 HL141186NHLBI NIH HHS R01 HL154522NHLBI NIH HHS T32 HL125204
6 · The paper itself

Abstract

Requirements for vesicle fusion within the heart remain poorly understood, despite the multitude of processes that necessitate proper intracellular trafficking within cardiomyocytes. Here, we show that Syntaxin 4 (STX4), a target-Soluble

Indexed as

calcium handlingconduction defectscongenital heart diseasedilated cardiomyopathySNARESyntaxin 4vesicular transportzebrafish

Identifiers

PMID35599850
PMCPMC9114686
OpenAlexW4224939653

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.