ReviewFrontiers in psychiatry2022
Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis.
Review in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 3 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Revisiting the link between childhood adversity and stress-sensitive brain regions in psychosis and bipolar disorder: a systematic review and meta-analysis.Translational psychiatry · 2026Pooled it
- Adverse childhood experiences and resting state functional connectivity of the triple brain network: a meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Global research landscape, knowledge structure, and emerging trends in adverse childhood experiences and personality disorders: a bibliometric analysis.Frontiers in psychiatry · 2026Pooled it
- Childhood peer abuse moderates associations of inflammation and cortisol with subcortical brain volume.European journal of psychotraumatology · 2026Article
- An etiological approach to psychosis: potential benefits for treatment, research and prevention.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Stress, needs, and behaviour: understanding chronic stress in pet domestic dogs (Canis lupus familiaris) from the prism of needs.Biological reviews of the Cambridge Philosophical Society · 2026Review
- The neuropsychological impact of early childhood trauma on cognitive development: A narrative review of mechanisms, outcomes, and interventions.PCN reports : psychiatry and clinical neurosciences · 2026Review
- Psychosomatic Burden and Childhood Trauma in Chronic Pruritus without Primary Dermatosis or Systemic Disease: A Case-control Study.Acta dermato-venereologica · 2026Article
- Identification of comprehensive genetic factors, pathways, and shared genetic architecture of putamen volume in adolescent cohort.Translational psychiatry · 2026Article
- Exploring the mediating role of functional connectivity in the association between violence exposure and psychopathology during early adolescence.Brain and cognition · 2026Article
- Maternal Mental Health and Labor Dysfunction: Prenatal Posttraumatic Stress Disorder, Labor Dystocia, and Unplanned Cesarean in a Cohort of Black Pregnant People.Research in nursing & health · 2026Article
- Octreotide Attenuates Anxiety-Like Behaviors and Cognitive Deficits in a Rat Model of Post-traumatic Stress Disorder.Neurochemical research · 2026Article
- Associations between childhood behavior and current cognitive and emotional function in adults with irritable bowel syndrome-a cross sectional retrospective study.BMC gastroenterology · 2026Observational
- Adverse childhood experiences among Kenyan adolescents: psychometric properties, prevalence rates and correlates.BMC psychiatry · 2026Article
- Sexual aggression and prenatal stress lead to poor maternal care and aggressive behaviour in male Wistar rat offspring.IBRO neuroscience reports · 2026Article
- Childhood paternal abuse and low paternal affection predict adult panic symptoms 18 years later via actigraphy-indexed sleep disruptions.Psychological medicine · 2026Article
- Brain network centrality following stress in adults with major depressive disorder and childhood trauma.Neurobiology of stress · 2026Article
- Serum S100B and Suicidal Ideation in Major Depressive Disorder: Evidence for a Trauma-Mediated Neurobiological Pathway.International journal of molecular sciences · 2026Article
- From Stress to Neurodegeneration: A New Look at the Pathogenesis of Parkinson's Disease.Biomedicines · 2026Review
- Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies of early life stress (ELS) demonstrate the long-lasting effects of acute and chronic stress on developmental trajectories. Such experiences can become biologically consolidated, creating individual vulnerability to psychological and psychiatric issues later in life. The hippocampus, amygdala, and the medial prefrontal cortex are all important limbic structures involved in the processes that undermine mental health. Hyperarousal of the sympathetic nervous system with sustained allostatic load along the Hypothalamic Pituitary Adrenal (HPA) axis and its connections has been theorized as the basis for adult psychopathology following early childhood trauma. In this review we synthesize current understandings and hypotheses concerning the neurobiological link between childhood trauma, the HPA axis, and adult psychiatric illness. We examine the mechanisms at play in the brain of the developing child and discuss how adverse environmental stimuli may become biologically incorporated into the structure and function of the adult brain
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.