ArticleJournal of tissue engineering
In vitro maturation and in vivo stability of bioprinted human nasal cartilage.
Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Advances in 3D Bioprinting for Scaffold-Based and Scaffold-Free Tissue Engineering and Regenerative Medicine.Gels (Basel, Switzerland) · 2026Review
- Bioprinting in Tissue Repair and Its ENT Applications.Polymers · 2026Review
- Tissue-Engineered Cartilage for Nasal Reconstruction: Mechanical Stimulation Through Bidirectional Bending.Annals of biomedical engineering · 2026Article
- Bioprinting for craniofacial reconstruction: A review of advancements, clinical use, and challenges.Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery · 2025Review
- Head and Neck 3D Bioprinting-A Review on Recent Advancements in Soft Tissue 3D Bioprinting and Medical Applications.Journal of functional biomaterials · 2025Review
- Cartilage Tissue Engineering in Multilayer Tissue Regeneration.Annals of biomedical engineering · 2025Review
- Human Septal Cartilage Tissue Engineering: Current Methodologies and Future Directions.Bioengineering (Basel, Switzerland) · 2024Review
- 3D Bioprinting of Hyaline Cartilage Using Nasal Chondrocytes.Annals of biomedical engineering · 2024Review
- A Contemporary Review of Trachea, Nose, and Ear Cartilage Bioengineering and Additive Manufacturing.Biomimetics (Basel, Switzerland) · 2024Review
- Recent advances in 3D bioprinted cartilage-mimicking constructs for applications in tissue engineering.Materials today. Bio · 2023Review
- 3D Bioprinting in Otolaryngology: A Review.Advanced healthcare materials · 2023Review
- Biomaterials and tissue engineering strategies for posterior lamellar eyelid reconstruction: Replacement or regeneration?Bioengineering & translational medicine · 2023Review
- Synthesis of biocompatible BSA-GMA and two-photon polymerization of 3D hydrogels with free radical type I photoinitiator.International journal of bioprinting · 2023Article
- 3D Bioprinting tissue analogs: Current development and translational implications.Journal of tissue engineeringReview
- Raising the Bar: Progress in 3D-Printed Hybrid Bone Scaffolds for Clinical Applications: A Review.Cell transplantationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The removal of skin cancer lesions on the nose often results in the loss of nasal cartilage. The cartilage loss is either surgically replaced with autologous cartilage or synthetic grafts. However, these replacement options come with donor-site morbidity and resorption issues. 3-dimensional (3D) bioprinting technology offers the opportunity to engineer anatomical-shaped autologous nasal cartilage grafts. The 3D bioprinted cartilage grafts need to embody a mechanically competent extracellular matrix (ECM) to allow for surgical suturing and resistance to contraction during scar tissue formation. We investigated the effect of culture period on ECM formation and mechanical properties of 3D bioprinted constructs of human nasal chondrocytes (hNC)-laden type I collagen hydrogel in vitro and in vivo. Tissue-engineered nasal cartilage constructs developed from hNC culture in clinically approved collagen type I and type III semi-permeable membrane scaffold served as control. The resulting 3D bioprinted engineered nasal cartilage constructs were comparable or better than the controls both in vitro and in vivo. This study demonstrates that 3D bioprinted constructs of engineered nasal cartilage are feasible options in nasal cartilage reconstructive surgeries.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.