ReviewPhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2022
Understanding brain states across spacetime informed by whole-brain modelling.
Review in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Characteristic spatiotemporal features of large-scale functional network architecture in posttraumatic stress disorder.Translational psychiatry · 2026Article
- Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- High-resolution Bayesian Virtual Epileptic Patient using neural field models.Network neuroscience (Cambridge, Mass.) · 2026Article
- Restoring oscillatory dynamics in Alzheimer's disease: A laminar whole-brain model of serotonergic psychedelic effects.Network neuroscience (Cambridge, Mass.) · 2026Article
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Modeling macroscopic brain dynamics with brain-inspired computing architecture.Nature communications · 2025Article
- Introducing e-Motions: a novel intraoperative test for social cognition mapping. Triple validation in normative, schizophrenia, and autism spectrum disorder populations.Acta neurochirurgica · 2025Article
- Impaired brain ability of older adults to transit and persist to latent states with well-organized structures at wakeful rest.GeroScience · 2025Article
- Human brain dynamics are shaped by rare long-range connections over and above cortical geometry.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Where are higher-order cognitive functions? The paradox of non-locality in awake cognitive mapping using a complex dynamic system framework.Frontiers in psychology · 2025Article
- Functional connectotomy of a whole-brain model reveals tumor-induced alterations to neuronal dynamics in glioma patients.Network neuroscience (Cambridge, Mass.) · 2025Article
- The Algorithmic Agent Perspective and Computational Neuropsychiatry: From Etiology to Advanced Therapy in Major Depressive Disorder.Entropy (Basel, Switzerland) · 2024Article
- Review of the Brain's Behaviour after Injury and Disease for Its Application in an Agent-Based Model (ABM).Biomimetics (Basel, Switzerland) · 2024Review
- Time-resolved coupling between connectome harmonics and subjective experience under the psychedelic DMT.bioRxiv : the preprint server for biology · 2024Article
- The flattening of spacetime hierarchy of theNational science review · 2024Article
- A synergetic turn in cognitive neuroscience of brain diseases.Trends in cognitive sciences · 2024Review
- Insomnia in Forensic Detainees: Is Salience Network the Common Pathway for Sleep, Neuropsychiatric, and Neurodegenerative Disorders?Journal of clinical medicine · 2024Review
- Neural Geometrodynamics, Complexity, and Plasticity: A Psychedelics Perspective.Entropy (Basel, Switzerland) · 2024Article
- Brain dynamics predictive of response to psilocybin for treatment-resistant depression.Brain communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to survive in a complex environment, the human brain relies on the ability to flexibly adapt ongoing behaviour according to intrinsic and extrinsic signals. This capability has been linked to specific whole-brain activity patterns whose relative stability (order) allows for consistent functioning, supported by sufficient intrinsic instability needed for optimal adaptability. The emergent, spontaneous balance between order and disorder in brain activity over spacetime underpins distinct brain states. For example, depression is characterized by excessively rigid, highly ordered states, while psychedelics can bring about more disordered, sometimes overly flexible states. Recent developments in systems, computational and theoretical neuroscience have started to make inroads into the characterization of such complex dynamics over space and time. Here, we review recent insights drawn from neuroimaging and whole-brain modelling motivating using mechanistic principles from dynamical system theory to study and characterize brain states. We show how different healthy and altered brain states are associated to characteristic spacetime dynamics which in turn may offer insights that in time can inspire new treatments for rebalancing brain states in disease. This article is part of the theme issue 'Emergent phenomena in complex physical and socio-technical systems: from cells to societies'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.