ArticleAnnals of neurology2022
Thrombectomy versus Medical Management in Mild Strokes due to Large Vessel Occlusion: Exploratory Analysis from the EXTEND-IA Trials and a Pooled International Cohort.
Article in Annals of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06179017 (Endovascular Treatment for Mild Stroke With Acute Anterior Circulation Large Vessel Occlusion：a Multicenter Randomized Controlled Trail), which is not on this map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Endovascular Treatment for Mild Stroke With Acute Anterior Circulation Large Vessel Occlusion：a Multicenter Randomized Controlled Trail
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Perfusion imaging-guided risk stratification and endovascular decision-making in low-NIHSS large-vessel occlusion stroke: a systematic review and exploratory meta-analysis.Journal of neurology · 2026Pooled it
- Endovascular therapy versus best medical care for acute ischemic stroke with distal medium vessel occlusion: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Tenecteplase versus alteplase for intravenous thrombolysis of acute ischemic stroke patients with large-vessel occlusion: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Endovascular treatment achieves better outcomes than best medical management in patients with M2 occlusion and high stroke severity: a meta-analysis.Journal of neurology · 2023Pooled it
- Endovascular Thrombectomy in Medium and Distal Vessel Occlusions: A Focused Guideline From the Society of Vascular and Interventional Neurology Guidelines and Practice Standards Committee.Stroke (Hoboken, N.J.) · 2026Review
- Endovascular therapy versus medical management for mild strokes due to medium and distal vessel occlusions.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Medical and endovascular treatment for acute large vessel occlusion with mild stroke: a real-world nationwide registry.Journal of neurointerventional surgery · 2026Article
- Comparing the Efficacy and Safety of Endovascular Therapy Versus Best Medical Treatment in Acute Ischemic Stroke Patients With Distal Medium Vessel Occlusion: A Systematic Review and Meta-Analysis.Journal of central nervous system disease · 2026Review
- A treatment-response framework for interpreting endovascular thrombectomy evidence: established practice, boundary expansion and unresolved frontiers.Frontiers in neurology · 2026Review
- Thrombectomy in Stroke Patients with Large Vessel Occlusion and Mild Symptoms: Insights from a Multicenter Observational Study.Translational stroke research · 2025Observational
- Thrombectomy for Ischemic Stroke Beyond 24 Hours: A Meta-Analysis.Life (Basel, Switzerland) · 2025Review
- Association of blood pressure parameters on early neurological deterioration in patients with mild stroke and large vessel occlusion following medical management.BMC neurology · 2025Article
- Mechanical thrombectomy for mild stroke with anterior circulation large vessel occlusion: a multicenter cohort study.Frontiers in neurology · 2025Article
- Prevalence and outcomes of mild stroke patients undergoing reperfusion therapy: A meta-analysis and SAFE recommendations for optimal management.Journal of central nervous system disease · 2025Article
- Low NIHSS score in large vessel occlusion stroke: optimal treatment and clinical controversies.Frontiers in neurology · 2025Review
- Influence of neurological severity and degree of dependence of patients after stroke on nursing workload: a retrospective cohort.Revista da Escola de Enfermagem da U S P · 2025Article
- Is Thrombectomy Effective for Large Vessel Occlusion Stroke Patients with Mild Symptoms? Meta-Analysis and Trial Sequential Analysis.Life (Basel, Switzerland) · 2024Article
- Perfusion Profiles May Differ Between Asymptomatic Versus Symptomatic Internal Carotid Artery Occlusion.Journal of stroke · 2024Article
- Mechanical Thrombectomy in the Late Presentation of Anterior Circulation Large Vessel Occlusion Stroke: A Guideline From the Society of Vascular and Interventional Neurology Guidelines and Practice Standards Committee.Stroke (Hoboken, N.J.) · 2023Article
- Advanced Imaging for Mild Stroke Patients: Selection for Acute Interventions.Annals of neurology · 2022Article
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Authors and funding
45 authors at 20 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was undertaken to evaluate functional and safety outcomes for endovascular thrombectomy (EVT) versus medical management (MM) in patients with large vessel occlusion (LVO) and mild neurological deficits, stratified by perfusion imaging mismatch.
methodsThe pooled cohort consisted of patients with National Institutes of Health Stroke Scale (NIHSS) < 6 and internal carotid artery (ICA), M1, or M2 occlusions from the Extending the Time for Thrombolysis in Emergecy Neurological Deficits - Intra-Arterial (EXTEND-IA) Trial, Tenecteplase vs Alteplase before Endovascular Thrombectomy in Ischemic Stroke (EXTEND-IA TNK) trials Part I/II and prospective data from 15 EVT centers from October 2010 to April 2020. RAPID software estimated ischemic core and mismatch. Patients receiving primary EVT (EVT
resultsOf 540 patients, 286 (53%) received EVT
interpretationOverall, EVT was not associated with improved clinical outcomes in mild strokes due to LVO, and sICH was increased. However, in patients with target mismatch profile, EVT was associated with increased functional independence. Perfusion imaging may be helpful to select mild stroke patients for EVT. ANN NEUROL 2022;92:364-378.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.