ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022
Bioactive Fish Scale Scaffolds with MSCs-Loading for Skin Flap Regeneration.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Algae-Integrated Optoelectronic Nanoplatform for Tumor Hypoxia Relief and Enhanced Photodynamic Therapy.Advanced healthcare materials · 2026Article
- Advances in Decellularization of Fish Wastes for Extracellular Matrix Extraction in Sustainable Tissue Engineering and Regenerative Medicine.Bioengineering (Basel, Switzerland) · 2026Review
- Immunomodulatory role of decellularized extracellular matrix in skin wound healing.Materials today. Bio · 2026Review
- Postoperative delirium in patients with free flap reconstruction after head and neck tumor surgery: influencing factors for severity and onset time, and a prediction model.BMC oral health · 2025Article
- METTL3-dependent mAutophagy · 2025Article
- A novel strategy for bone defect repair: Stromal cell-derived factor 1α sustained-release acellular fish scale scaffolds combined with injection of bone marrow mesenchymal stem cells promote bone regeneration.Materials today. Bio · 2025Article
- Organoid-Like Neurovascular Spheroids Promote the Recovery of Hypoxic-Ischemic Skin Flaps Through the Activation of Autophagy.Advanced healthcare materials · 2025Article
- Polydopamine-functionalized acellular fish scale scaffolds for accelerated bone tissue regeneration.RSC advances · 2025Article
- Novel Decellularization Scheme for Preparing Acellular Fish Scale Scaffolds for Bone Tissue Engineering.ACS omega · 2025Article
- Decellularization of fish tissues for tissue engineering and regenerative medicine applications.Regenerative biomaterials · 2025Review
- Fish-derived biomaterials for tissue engineering: advances in scaffold fabrication and applications in regenerative medicine and cancer therapy.Theranostics · 2025Review
- Microfluidic 3D printing hydrogels based on fish liver decellularized extracellular matrix for liver regeneration.Smart medicine · 2024Article
- Development of Biomaterials to Modulate the Function of Macrophages in Wound Healing.Bioengineering (Basel, Switzerland) · 2024Review
- The role of adipose tissue-derived stromal cells, macrophages and bioscaffolds in cutaneous wound repair.Biology direct · 2024Review
- Apoptotic Bodies Derived from Fibroblast-Like Cells in Subcutaneous Connective Tissue Inhibit Ferroptosis in Ischaemic Flaps via the miR-339-5p/KEAP1/Nrf2 Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Effects of Various Decellularization Methods for the Development of Decellularized Extracellular Matrix from Tilapia (International journal of biomaterials · 2024Article
- Regulation of inflammation during wound healing: the function of mesenchymal stem cells and strategies for therapeutic enhancement.Frontiers in pharmacology · 2024Review
- Microenvironment Remodeling Self-Healing Hydrogel for Promoting Flap Survival.Biomaterials research · 2024Article
- Decellularized Tumor Tissues Integrated with Polydopamine for Wound Healing.Research (Washington, D.C.) · 2024Article
- Mesenchymal Stem Cell Exosome-Integrated Antibacterial Hydrogels for Nasal Mucosal Injury Treatment.Research (Washington, D.C.) · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Skin flap transplantations are common methods for covering and repairing tissue defects in surgery, while the survival rates of these skin flaps are still low due to the vascular crisis and necrosis. To improve this situation, herein a novel biohybrid scaffold is proposed by integrating the advantages of anisotropic fish scales and mesenchymal stem cells (MSCs) for skin flap regeneration. The fish scale scaffold is obtained through its decellularization and decalcification processes, which reserved intact collagen, glycosaminoglycan, and other endogenous growth factors for MSCs and human vascular endothelial cells proliferation. As the scaffold maintains intrinsic anisotropic structures on both surfaces, the proliferative cells can be elongated along the aligned structures on the fish scale, which endow them the capacity to differentiate into multiple directions. Based on these features, it is demonstrated from an in vivo experiment that the MSCs-loading fish scale scaffolds can effectively convert the activated inflammatory macrophages into anti-inflammatory properties, reduce the inflammation around the flap, and improve the survival rate. These results indicate that the MSCs-loading fish scale scaffold is suitable and has the potential for skin flap regeneration and functional recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.