Evidence map›Paper›PMID 35599295›Full record

Trial reportPsychophysiology2022

Effect of high-intensity interval training on hippocampal metabolism in older adolescents.

Sarah Ruth Valkenborghs, Charles H Hillman, Oun Al-Iedani, Michael Nilsson, Jordan J Smith, Angus Aaron Leahy, Simon K Harries, Saadallah Ramadan, David Revalds Lubans

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  8. Article
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  12. Can 16 Minutes of HIIT Improve Attentional Resources in Young Students?Journal of functional morphology and kinesiology · 2023
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Sarah Ruth ValkenborghsSchool of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales, Australia.ORCID 0000-0003-2259-4682
Charles H HillmanCenter for Cognitive & Brain Health, Department of Psychology, Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, Boston, Massachusetts, USA.ORCID 0000-0002-3722-5612
Oun Al-IedaniSchool of Health Sciences, The University of Newcastle, Callaghan, New South Wales, Australia.ORCID 0000-0002-3112-4482
Michael NilssonCentre for Rehab Innovations, The University of Newcastle, Callaghan, New South Wales, Australia.ORCID 0000-0002-8826-1621
Jordan J SmithCentre for Active Living and Learning, The University of Newcastle, Callaghan, New South Wales, Australia.
Angus Aaron LeahyCentre for Active Living and Learning, The University of Newcastle, Callaghan, New South Wales, Australia.ORCID 0000-0003-2147-9420
Simon K HarriesCentre for Active Living and Learning, The University of Newcastle, Callaghan, New South Wales, Australia.
Saadallah RamadanSchool of Health Sciences, The University of Newcastle, Callaghan, New South Wales, Australia.ORCID 0000-0003-3874-7866
David Revalds LubansCentre for Active Living and Learning, The University of Newcastle, Callaghan, New South Wales, Australia.ORCID 0000-0002-0204-8257
University of Newcastle Australia · AUNortheastern University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although well-evidenced in older adults, the effects of exercise on the hippocampus in youth are relatively unknown. This study examined the impact of a 6-month school-based physical activity intervention on hippocampal metabolism in adolescents using magnetic resonance spectroscopy. A subset of lower fit older adolescents [N = 56, 61% female, 16.1 ± 0.4 years] was included from four secondary schools (10 classes) in New South Wales, Australia, who were participating in a larger cluster randomized controlled trial. Participants were randomized to the Burn 2 Learn (B2L) intervention (five classes, 30 participants) or a control group (five classes, 26 participants). Changes in hippocampal metabolism were assessed using linear mixed models adjusted for clustering at the class level. We observed group-by-time effects for the B2L intervention on N-acetylaspartate (NAA) (+2.66 mmol/L, 95% CI 0.20 to 5.11, d = 0.66) and glutamate+glutamine (Glx) (+3.38 mmol/L, 95% CI 0.34 to 6.42, d = 0.67) in the left hippocampus. Increases in left hippocampal NAA and Glx concentrations were associated with improvements in cardiorespiratory fitness (NAA: r

Indexed as

High-Intensity Interval TrainingAdolescentAgedFemaleGlutamatesGlutamineHippocampusHumansMagnetic Resonance SpectroscopyMaleGlutamatesGlutamineadolescentscognitionexerciseworking memory

Identifiers

PMID35599295
PMCPMC9787522
OpenAlexW4281296206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.