ReviewTrends in neurosciences2022
Construction of complex memories via parallel distributed cortical-subcortical iterative integration.
Review in Trends in neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
- Neurophysiological correlates to the human brain complexity through q-statistical analysis of electroencephalogram.Scientific reports · 2025Article
- Endocannabinoids disinhibit the ventral tegmental nucleus of Gudden to dorsal premammillary nucleus pathway to enhance escape behavior following learned threat experience.Nature communications · 2025Article
- A cortico-subcortical loop for motor control via the pontine reticular formation.Cell reports · 2025Article
- Different frequencies of human scalp-recorded theta activity may index integration of activity in distinct recurrent cortico-subcortical mnemonic networks.Frontiers in behavioral neuroscience · 2025Review
- Is lack of goal-conflict-specific rhythmicity a biomarker for treatment resistance in generalised anxiety but not social anxiety or major depression?Journal of psychopharmacology (Oxford, England) · 2024Article
- Electrophysiological Properties of the Medial Mammillary Bodies across the Sleep-Wake Cycle.eNeuro · 2024Article
- Impairments in the early consolidation of spatial memories via group II mGluR agonism in the mammillary bodies.Scientific reports · 2024Article
- Joint diffusional kurtosis magnetic resonance imaging analysis of white matter and the thalamus to identify subcortical ischemic vascular disease.Scientific reports · 2024Article
- The Limbic System in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder: A Longitudinal Structural Magnetic Resonance Imaging Analysis.Biological psychiatry global open science · 2024Article
- Excitation/Inhibition balance relates to cognitive function and gene expression in temporal lobe epilepsy: a high density EEG assessment with aperiodic exponent.Brain communications · 2024Article
- The effects of slow wave sleep characteristics on semantic, episodic, and procedural memory in people with epilepsy.Frontiers in pharmacology · 2024Article
- Reduced mammillary body volume in individuals with a schizophrenia diagnosis: an analysis of the COBRE data set.Schizophrenia (Heidelberg, Germany) · 2023Article
- Article
- Structural Connectivity Changes After Fornix Transection in Macaques Using Probabilistic Diffusion Tractography.Advances in experimental medicine and biology · 2023Article
- Normative mammillary body volumes: From the neonatal period to young adult.Neuroimage. Reports · 2022Article
- Theta dominates cross-frequency coupling in hippocampal-medial entorhinal circuit during awake-behavior in rats.iScience · 2022Article
- Prefrontal and hippocampal theta rhythm show anxiolytic-like changes during periaqueductal-elicited "panic" in rats.Hippocampus · 2022Article
- Transcranial alternating current stimulation combined with sound stimulation improves cognitive function in patients with Alzheimer's disease: Study protocol for a randomized controlled trial.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The construction of complex engrams requires hippocampal-cortical interactions. These include both direct interactions and ones via often-overlooked subcortical loops. Here, we review the anatomical organization of a hierarchy of parallel 'Papez' loops through the hypothalamus that are homologous in mammals from rats to humans. These hypothalamic loops supplement direct hippocampal-cortical connections with iterative reprocessing paced by theta rhythmicity. We couple existing anatomy and lesion data with theory to propose that recirculation in these loops progressively enhances desired connections, while reducing interference from competing external goals and internal associations. This increases the signal-to-noise ratio in the distributed engrams (neocortical and cerebellar) necessary for complex learning and memory. The hypothalamic nodes provide key motivational input for engram enhancement during consolidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.