Evidence map›Paper›PMID 35598970›Full record

ArticleThe Journal of reproduction and development2022

Genetically engineered animal models for Marfan syndrome: challenges associated with the generation of pig models for diseases caused by haploinsufficiency.

Naomi Jack, Tomoyuki Muto, Keigo Iemitsu, Tamaki Watanabe, Kazuhiro Umeyama, Jun Ohgane, Hiroshi Nagashima

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of reproduction and development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Naomi JackMeiji University International Institute for Bio-Resource Research, Kawasaki 214-8571, Japan.
Tomoyuki MutoLaboratory of Medical Bioengineering, Department of Life Sciences, School of Agriculture, Meiji University, Kawasaki 214-8571, Japan.
Keigo IemitsuLaboratory of Medical Bioengineering, Department of Life Sciences, School of Agriculture, Meiji University, Kawasaki 214-8571, Japan.
Tamaki WatanabeLaboratory of Medical Bioengineering, Department of Life Sciences, School of Agriculture, Meiji University, Kawasaki 214-8571, Japan.
Kazuhiro UmeyamaMeiji University International Institute for Bio-Resource Research, Kawasaki 214-8571, Japan.
Jun OhganeMeiji University International Institute for Bio-Resource Research, Kawasaki 214-8571, Japan.
Hiroshi NagashimaMeiji University International Institute for Bio-Resource Research, Kawasaki 214-8571, Japan.
Meiji University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent developments in reproductive biology have enabled the generation of genetically engineered pigs as models for inherited human diseases. Although a variety of such models for monogenic diseases are currently available, reproduction of human diseases caused by haploinsufficiency remains a major challenge. The present study compares the phenotypes of mouse and pig models of Marfan syndrome (MFS), with a special focus on the expressivity and penetrance of associated symptoms. Furthermore, investigation of the gene regulation mechanisms associated with haploinsufficiency will be of immense utility in developing faithful MFS pig models.

Indexed as

Marfan SyndromeAnimalsAnimals, Genetically ModifiedFibrillin-1HaploinsufficiencyHumansMutationPhenotypeSwineFibrillin-1Disease model pigFBN1Genetic engineeringHaploinsufficiencyMarfan syndrome

Identifiers

PMID35598970
PMCPMC9334321
OpenAlexW4282933792

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.