ArticleObesity (Silver Spring, Md.)2022
A multivariant recall-by-genotype study of the metabolomic signature of BMI.
Article in Obesity (Silver Spring, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Eight weeks of aerobic exercise, but not four, improves insulin sensitivity and cardiovascular performance in young women.Scientific reports · 2025Trial
- Article
- Leveraging Multiomic Signatures to Predict Body Composition.Advances in nutrition (Bethesda, Md.) · 2026Review
- Variant-to-function approaches for adipose tissue: Insights into cardiometabolic disorders.Cell genomics · 2025Review
- Untargeted metabolomics data in the By-Band-Sleeve trial and ALSPAC: integrating clinical trial and population cohort data.Wellcome open research · 2025Article
- Metabolic liability for weight gain in early adulthood.Cell reports. Medicine · 2024Article
- Targeted metabolomics-based understanding of the sleep disturbances in drug-naïve patients with schizophrenia.BMC psychiatry · 2024Article
- The association between body mass index and metabolite response to a liquid mixed meal challenge: a Mendelian randomization study.The American journal of clinical nutrition · 2024Article
- The metabolomic profiling of total fat and fat distribution in a multi-cohort study of women and men.Scientific reports · 2023Article
- A multivariant recall-by-genotype study of the metabolomic signature of BMI.Obesity (Silver Spring, Md.) · 2022Article
- A multivariant recall-by-genotype study of the metabolomic signature of BMI.Obesity (Silver Spring, Md.) · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThis study estimated the effect of BMI on circulating metabolites in young adults using a recall-by-genotype study design.
methodsA recall-by-genotype study was implemented in the Avon Longitudinal Study of Parents and Children. Samples from 756 participants were selected for untargeted metabolomics analysis based on low versus high genetic liability for higher BMI defined by a genetic risk score (GRS). Regression analyses were performed to investigate associations between BMI GRS group and relative abundance of 973 metabolites.
resultsAfter correction for multiple testing, 29 metabolites were associated with BMI GRS group. Bilirubin was among the most strongly associated metabolites, with reduced levels measured in individuals in the high-BMI GRS group (β = -0.32, 95% CI: -0.46 to -0.18, Benjamini-Hochberg adjusted p = 0.005). This study observed associations between BMI GRS group and the levels of several potentially diet-related metabolites, including hippurate, which had lower mean abundance in individuals in the high-BMI GRS group (β = -0.29, 95% CI: -0.44 to -0.15, Benjamini-Hochberg adjusted p = 0.008).
conclusionsTogether with existing literature, these results suggest that a genetic predisposition to higher BMI captures differences in metabolism leading to adiposity gain. In the absence of prospective data, separating these effects from the downstream consequences of weight gain is challenging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.