Evidence map›Paper›PMID 35598641›Full record

ArticleMathematical biosciences2022

Data-driven models for replication kinetics of Orthohantavirus infections.

Alison Adams, Quiyana M Murphy, Owen P Dougherty, Aubrey M Sawyer, Fan Bai, Christina J Edholm, Evan P Williams, Linda J S Allen, Colleen B Jonsson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mathematical biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 3 countries.

Alison AdamsUT-ORNL Graduate School of Genome Science and Technology, University of Tennessee, Knoxville, TN, USA. Electronic address: aadams76@utk.edu.
Quiyana M MurphyDepartment of Mathematics, Virginia Tech, Blacksburg, VA, USA.
Owen P DoughertyDepartment of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Aubrey M SawyerDivision of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Fan BaiDivision of Science and Technology, Beijing Normal University - Hong Kong Baptist University United International College, Zhuhai, Guangdong, China.
Christina J EdholmDepartment of Mathematics, Scripps College, Claremont, CA, USA.
Evan P WilliamsDepartment of Microbiology, Immunology, Biochemistry, University of Tennessee, Health Science Center, Memphis, USA.
Linda J S AllenDepartment of Mathematics and Statistics, Texas Tech University, Lubbock, TX, USA.
Colleen B JonssonDepartment of Microbiology, Immunology, Biochemistry, University of Tennessee, Health Science Center, Memphis, USA.
University of Tennessee Health Science Center · USBeijing Normal University · CNNorthwestern University · USScripps College · USTexas Tech University · USUniversity of Tennessee at Knoxville · USVanderbilt University · USVirginia Tech · US

Funding

Evolutonary Mechanisms of RNA Virus Host SwitchingR01AI103053 · NIAID · UNIVERSITY OF TENNESSEE KNOXVILLE · PI JONSSON, COLLEEN B · 2014 to 2017
$1.7M
NIAID NIH HHS R01 AI103053
6 · The paper itself

Abstract

The Hantaviridae constitute a family of viruses harbored by mice, rats, shrews, voles, moles and bats. Intriguingly, only viruses harbored by mice and rats may cause disease in humans with up to 40% case fatality rate in the Americas. Transmission of virus from rodents to humans occurs via the respiratory route and results in replication of the virus in the microvascular endothelial cells of the lung or kidney. Understanding the replication kinetics of these viruses in various cell types and how replication is abrogated by the host is critical to the development of effective therapeutics for treatment for which there are none. We formulate several new ordinary differential equation (ODE) models to examine the replication kinetics of Prospect Hill orthohantavirus (PHV). The models are distinguished by the distribution of the viral replication delay. A new threshold, R

Indexed as

Endothelial CellsOrthohantavirusAnimalsChlorocebus aethiopsKineticsMiceRatsVero CellsVirus ReplicationFinal density relationIn vitro dataOrthohantavirusWithin-host

Identifiers

PMID35598641
PMCPMC12404180
OpenAlexW4280622739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.