Evidence map›Paper›PMID 35598593›Full record

ArticleNeonatology2022

Development and Validation of a Mortality Prediction Model in Extremely Low Gestational Age Neonates.

Alvaro Moreira, Domenico Benvenuto, Christopher Fox-Good, Yasmeen Alayli, Mary Evans, Baldvin Jonsson, Stellan Hakansson, Nathan Harper, Jennifer Kim, Mikael Norman and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Neonatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. NewbornGenes · 2025
    Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. [Clinical characteristics ofZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Article
  9. Review
  10. Article
  11. [Risk factors and prognosis of hypotension within 72 hours after birth in extremely preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Alvaro MoreiraDepartment of Pediatrics, University of Texas Health San Antonio, San Antonio, Texas, USA.
Domenico BenvenutoDepartment of Biostatistics, Epidemiology and Molecular Pathology, Università Campus Bio-Medico di Roma, Rome, Italy.
Christopher Fox-GoodDepartment of Pediatrics, University of Texas Health San Antonio, San Antonio, Texas, USA.
Yasmeen AlayliDepartment of Pediatrics, University of Texas Health San Antonio, San Antonio, Texas, USA.
Mary EvansDepartment of Pediatrics, University of Texas Health San Antonio, San Antonio, Texas, USA.
Baldvin JonssonDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Stellan HakanssonDepartment of Clinical Sciences/Pediatrics, Umeå University, Umeå, Sweden.
Nathan HarperVeterans Administration Research Center for AIDS and HIV-1 Infection and Center for Personalized Medicine, South Texas Veterans Health Care System, San Antonio, Texas, USA.
Jennifer KimDepartment of Pediatrics, University of Texas Health San Antonio, San Antonio, Texas, USA.
Mikael NormanDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Matteo BruschettiniDepartment of Pediatrics, Lund University, Lund, Sweden.
The University of Texas Health Science Center at San Antonio · USKarolinska Institutet · SELund University · SESouth Texas Veterans Health Care System · USUmeå University · SEUniversità Campus Bio-Medico · IT

Funding

Genomic determinants of bronchopulmonary dysplasia development in humans and an animal modelK23HD101701 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MOREIRA, ALVARO G · 2021 to 2024
$652k
NICHD NIH HHS K23 HD101701
6 · The paper itself

Abstract

introductionUnderstanding factors that associate with neonatal death may lead to strategies or interventions that can aid clinicians and inform families.

objectiveThe aim of the study was to develop an early prediction model of neonatal death in extremely low gestational age (ELGA, <28 weeks) neonates.

methodsA predictive cohort study of ELGA neonates was derived from the Swedish Neonatal Quality Register between the years 2011 to May 2021. The goal was to use readily available clinical variables, collected within the first hour of birth, to predict in-hospital death. Data were split into a train cohort (80%) to build the model and tested in 20% of randomly selected neonates. Model performance was assessed via area under the receiver operating characteristic curve (AUC) and compared to validated mortality prediction models and an external cohort of neonates.

resultsAmong 3,752 live-born extremely preterm infants (46% girls), in-hospital mortality was 18% (n = 685). The median gestational age and birth weight were 25.0 weeks (interquartile range [IQR] 24.0, 27.0) and 780 g (IQR 620, 940), respectively. The proposed model consisted of three variables: birth weight (grams), Apgar score at 5 min of age, and gestational age (weeks). The BAG model had an AUC of 76.9% with a 95% confidence interval (CI) (72.6%, 81.3%), while birth weight and gestational age had an AUC of 73.1% (95% CI: 68.4%,77.9%) and 71.3% (66.3%, 76.2%). In the validation cohort, the BAG model had an AUC of 68.9%.

conclusionThe BAG model is a new mortality prediction model in ELGA neonates that was developed using readily available information.

Indexed as

Perinatal DeathBirth WeightCohort StudiesFemaleGestational AgeHospital MortalityHumansInfantInfant, Extremely PrematureInfant MortalityInfant, NewbornMaleMortalityNeonatePredictionPreterm

Identifiers

PMID35598593
PMCPMC9296601
OpenAlexW4281263020

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.