Evidence map›Paper›PMID 35598384›Full record

ArticleTranslational oncology2022

Preoperative neutrophil-to-lymphocyte ratio (preNLR) for the assessment of tumor characteristics in lung adenocarcinoma patients with brain metastasis.

Huanhuan Cui, Yuechao Yang, Mingtao Feng, Yang Gao, Liangdong Li, Wenjing Tu, Xin Chen, Bin Hao, Sen Li, Deheng Li and 3 more

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Article in Translational oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

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5citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Huanhuan CuiDepartment of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai 200433, China.
Yuechao YangDepartment of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai 200433, China.
Mingtao FengDepartment of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai 200433, China.
Yang GaoDepartment of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai 200433, China.
Liangdong LiDepartment of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai 200433, China.
Wenjing TuDepartment of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai 200433, China.
Xin ChenDepartment of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai 200433, China.
Bin HaoDepartment of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai 200433, China.
Sen LiDepartment of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai 200433, China.
Deheng LiDepartment of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai 200433, China.
Lei ChenDepartment of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai 200433, China.
Changshuai ZhouDepartment of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai 200433, China. Electronic address: shiwa1990@163.com.
Yiqun CaoDepartment of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai 200433, China. Electronic address: gem23@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesBrain metastases from lung adenocarcinoma cause significant patient mortality. This study aims to evaluate the role of preoperative Neutrophil-to-Lymphocyte ratio (preNLR) in predicting the survival and prognosis of Lung adenocarcinoma (LUAD) patients with brain metastasis (BM) and provide more references for predicting peritumoral edema.

methodsWe retrospectively reviewed 125 LUAD-BM patients who had undergone surgical resection from December 2015 to December 2020. The clinical characteristic, demographic, MRI data, and preNLR within 24-48 h before craniotomy were collected. Patients were divided into two groups based on preNLR (high NLR and low NLR), with cutoff values determined by receiver operating characteristic (ROC) analysis. Association between preoperative NLR and clinical features was determined by using Pearson chi-squared tests. Uni- and multivariate analyzes were performed to compare the overall survival (OS) of clinical features.

resultsThe patients were divided into NLR-low (64 patients) and NLR-high (61 patients) groups based on receiver operating characteristic analysis of NLR area. According to correlation analysis, a high preNLR (NLR≥2.8) is associated with the both supra- and infratentorial location involved (P = 0.017) and a greater incidence of severe peritumoral edema (P = 0.038). By multivariable analysis, age ≥ 65 years (P = 0.011), KPS < 70 (P = 0.043), elevated preNLR (P = 0.013), extracerebral metastases (P = 0.003), EGFR/ALK+ (P = 0.037), postoperative radiotherapy (P = 0.017) and targeted therapy (P = 0.007) were independent prognostic factors. OS nomogram was constructed based on cox model and model performance was examined (AUC = 0.935).

conclusionsPreNLR may serve as a prognosis indicator in LUAD patients with brain metastasis, and high preNLR tends to be positively associate with multiple locations and severe peritumoral edema.

Indexed as

Brain metastasisLung adenocarcinomaNeutrophil-to-lymphocyte ratioPeritumoral edema

Identifiers

PMID35598384
PMCPMC9126952

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