ReviewExperimental physiology2022
Are there sex differences in risk for exertional heat stroke? A translational approach.
Review in Experimental physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Heatstroke Awareness and Preventive Behaviors Among Automotive Maintenance Workers in Outdoor Environments: A Cross-Sectional Study in Japan.Healthcare (Basel, Switzerland) · 2026Article
- GPER agonist G1 suppresses neuronal apoptosis mediated by endoplasmic reticulum stress after exertional heat stroke injury.Scientific reports · 2026Article
- Individual-Level, Multi-Provincial Analysis of High Temperature and Heat-Related Illness Association - China, 2013-2022.China CDC weekly · 2025Article
- Differential intestinal injury and unchanged systemic inflammatory responses to leg and whole-body passive hyperthermia in healthy humans.Experimental physiology · 2025Article
- Using environmental and exercise physiology to address gender inequalities in climate change and occupational health research.Experimental physiology · 2025Review
- Youth suicidality risk relative to ambient temperature and heatwaves across climate zones: A time series analysis of emergency department presentations in New South Wales, Australia.The Australian and New Zealand journal of psychiatry · 2025Article
- Early life adversity has sex-dependent effects on survival across the lifespan in rhesus macaques.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Exertional Heatstroke Survivors' Knowledge and Beliefs About Exertional Heatstroke Diagnosis, Treatment, and Return to Play.Journal of athletic training · 2024Article
- Exertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression, and impaired satellite cell function in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Beating the heat: military training and operations in the era of global warming.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- Exertional Heat Stroke and Rhabdomyolysis: A Medical Record Review and Patient Perspective on Management and Long-Term Symptoms.Sports medicine - open · 2023Article
- Ovariectomy aggravates the pathophysiological response to exertional heat stroke in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Relatively minor influence of individual characteristics on critical wet-bulb globe temperature (WBGT) limits during light activity in young adults (PSU HEAT Project).Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Potential impact of metabolic syndrome on cognitive function in US firefighters.Frontiers in public health · 2023Article
- Exertional heat stroke in sport and the military: epidemiology and mitigation.Experimental physiology · 2022Review
- The impact of castration on physiological responses to exertional heat stroke in mice.PloS one · 2022Article
- Exertional heat stroke: pathophysiology and risk factors.BMJ medicine · 2022Review
- Treating exertional heat stroke: Limited understanding of the female response to cold water immersion.Frontiers in physiology · 2022Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NEW
findingsWhat is the topic of this review? Whether there are sex differences in exertional heat stroke. What advances does it highlight? This review utilizes a translational model between animal and human research to explore possible physical and physiological differences with respect to risk and treatment of exertional heat stroke. ABSTRACT: Exertional heat stroke (EHS) is a potentially fatal condition brought about by a combination of physical activity and heat stress and resulting in central nervous system dysfunction and organ damage. EHS impacts several hundred individuals each year ranging from military personnel, athletes, to occupational workers. Understanding the pathophysiology and risk factors can aid in reducing EHS across the globe. While we know there are differences between sexes in mechanisms of thermoregulation, there is currently not a clear understanding of if or how those differences impact EHS risk. The purpose of this review is to assess the current status of the literature surrounding EHS from risk factors to treatment using both animal and human models. We use a translational approach, considering both animal and human research to elucidate the possible influence of female sex hormones on temperature regulation and performance in the heat and highlight the specific areas with limited research. While more work is necessary to comprehensively understand these differences, the current research presented provides a good framework for future investigations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.