Evidence map›Paper›PMID 35598093›Full record

ArticleRespirology (Carlton, Vic.)2022

Examining the impact of multilevel upper airway surgery on the obstructive sleep apnoea endotypes and their utility in predicting surgical outcomes.

Ai-Ming Wong, Shane A Landry, Simon A Joosten, Luke D J Thomson, Anthony Turton, Jeremy Stonehouse, Darren R Mansfield, Glen Burgess, Andrew Hays, Scott A Sands and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respirology (Carlton, Vic.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Ai-Ming WongMonash Lung, Sleep, Allergy & Immunology, Monash Health, Monash Medical Centre, Melbourne, Victoria, Australia.ORCID 0000-0002-8325-705X
Shane A LandryDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria.ORCID 0000-0002-9041-3655
Simon A JoostenMonash Lung, Sleep, Allergy & Immunology, Monash Health, Monash Medical Centre, Melbourne, Victoria, Australia.ORCID 0000-0002-7909-8025
Luke D J ThomsonDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria.ORCID 0000-0001-5568-775X
Anthony TurtonMonash Lung, Sleep, Allergy & Immunology, Monash Health, Monash Medical Centre, Melbourne, Victoria, Australia.
Jeremy StonehouseMonash Lung, Sleep, Allergy & Immunology, Monash Health, Monash Medical Centre, Melbourne, Victoria, Australia.
Darren R MansfieldMonash Lung, Sleep, Allergy & Immunology, Monash Health, Monash Medical Centre, Melbourne, Victoria, Australia.ORCID 0000-0002-0565-9846
Glen BurgessDepartment of Ear, Nose and Throat, Monash Health, Melbourne, Australia.
Andrew HaysDepartment of Ear, Nose and Throat, Monash Health, Melbourne, Australia.
Scott A SandsDivision of Sleep and Circadian Disorders, Department of Medicine and Neurology, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Christopher AndaraDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria.
Caroline J BeattyDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria.ORCID 0000-0002-0808-1429
Garun S HamiltonMonash Lung, Sleep, Allergy & Immunology, Monash Health, Monash Medical Centre, Melbourne, Victoria, Australia.ORCID 0000-0002-1744-2839
Bradley A EdwardsDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria.ORCID 0000-0001-9383-1644

Funding

A Novel Pharmacological Therapy for Obstructive Sleep ApneaR01HL146697 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SANDS, SCOTT A · 2019 to 2023
$3.4M
NHLBI NIH HHS R01 HL146697
6 · The paper itself

Abstract

BACKGROUND AND

objectiveUpper airway surgery for obstructive sleep apnoea (OSA) is an alternative treatment for patients who are intolerant of continuous positive airway pressure (CPAP). However, upper airway surgery has variable treatment efficacy with no reliable predictors of response. While we now know that there are several endotypes contributing to OSA (i.e., upper airway collapsibility, airway muscle response/compensation, respiratory arousal threshold and loop gain), no study to date has examined: (i) how upper airway surgery affects all four OSA endotypes, (ii) whether knowledge of baseline OSA endotypes predicts response to surgery and (iii) whether there are any differences when OSA endotypes are measured using the CPAP dial-down or clinical polysomnographic (PSG) methods.

methodsWe prospectively studied 23 OSA patients before and ≥3 months after multilevel upper airway surgery. Participants underwent clinical and research PSG to measure OSA severity (apnoea-hypopnoea index [AHI]) and endotypes (measured in supine non-rapid eye movement [NREM]). Values are presented as mean ± SD or median (interquartile range).

resultsSurgery reduced the AHI

conclusionSurgery unpredictably alters upper airway collapsibility but does not alter the non-anatomical endotypes. There are no baseline predictors of response to surgery.

Indexed as

Sleep Apnea, ObstructiveArousalContinuous Positive Airway PressureHumansRespiratory SystemTreatment Outcomeobstructive sleep apnoeaOSA endotypespredictorupper airway surgeryventilation

Identifiers

PMID35598093
PMCPMC9542009

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.