Evidence map›Paper›PMID 35597997›Full record

ArticleBMC research notes2022

Examining the role of person-to-person transmission during a verocytotoxigenic Escherichia coli outbreak in Ontario, Canada.

Roksolana Hovdey, Jan M Sargeant, David N Fisman, Amy L Greer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Antimicrobial ResistantPathogens (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Roksolana HovdeyDepartment of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Jan M SargeantDepartment of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
David N FismanDepartment of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Amy L GreerDepartment of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada. agreer@uoguelph.ca.ORCID http://orcid.org/0000-0002-6366-0458

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePerson-to-person transmission can occur during outbreaks of verotoxigenic Escherichia coli (VTEC), however the impact of this transmission route is not well understood. This study aimed to examine the role of person-to-person transmission during a VTEC outbreak, and how targeting this route may reduce outbreak size. A deterministic compartmental model describing a VTEC outbreak was constructed and fit to data from a 2008 outbreak in Ontario, Canada. Using the best-fit model, simulations were run to calculate the: reduction in transmission rate after implementing interventions, proportion of cases infected through both transmission routes, and number of cases prevented by interventions. Latin hypercube sensitivity analysis was conducted to examine the sensitivity of the outbreak size to the model parameters.

resultsBased on the best-fit model, ~ 14.25% of the cases likely arose due to person-to-person transmission. Interventions reduced this transmission rate by ~ 73%, causing a reduction in outbreak size of ~ 17% (47 cases). Sensitivity analysis showed that the model was highly sensitive to changes in all parameters of the model. The model demonstrates that person-to-person could be an important transmission route during VTEC outbreaks. Targeting this route of transmission through hand hygiene and work exclusions could reduce the final outbreak size.

Indexed as

Escherichia coli InfectionsShiga-Toxigenic Escherichia coliDisease OutbreaksHumansOntarioDisease modellingDisease transmissionEnteric infectionsEscherichia coliModellingMulti-chain transmissionOutbreakPublic healthVTEC

Identifiers

PMID35597997
PMCPMC9123793

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.