Evidence map›Paper›PMID 35597974›Full record

ArticlePilot and feasibility studies2022

Feasibility and acceptability of high-intensity interval training and moderate-intensity continuous training in kidney transplant recipients: the PACE-KD study.

Roseanne E Billany, Alice C Smith, Ganisha M Hutchinson, Matthew P M Graham-Brown, Daniel G D Nixon, Nicolette C Bishop

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pilot and feasibility studies, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023
    Pooled it
  3. Trial
  4. Article
  5. Review
  6. SupervisedWorld journal of transplantation · 2024
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Roseanne E BillanyDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Alice C SmithJohn Walls Renal Unit, University Hospitals of Leicester NHS Trust, Leicester, UK.
Ganisha M HutchinsonDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.
Matthew P M Graham-BrownDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Daniel G D NixonJohn Walls Renal Unit, University Hospitals of Leicester NHS Trust, Leicester, UK.
Nicolette C BishopSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, LE11 3TU, UK. N.C.Bishop@lboro.ac.uk.ORCID http://orcid.org/0000-0001-6221-3907
University of Leicester · GBLoughborough University · GB

Funding

Heart Research UK RG2650/15/18
6 · The paper itself

Abstract

backgroundKidney transplant recipients (KTRs) exhibit unique elevated inflammation, impaired immune function, and increased cardiovascular risk. Although exercise reduces cardiovascular risk, there is limited research on this population, particularly surrounding novel high-intensity interval training (HIIT). The purpose of this pilot study was to determine the feasibility and acceptability of HIIT in KTRs.

methodsTwenty KTRs (male 14; eGFR 58±19 mL/min/1.73 m

resultsTwenty participants completed the intervention, and 8 of whom achieved the required intensity based on power output (HIIT A, 0/6 [0%]; HIITB, 3/8 [38%]; MICT, 5/6 [83%]). Participants completed 92% of the 24 sessions with 105 cancelled and rescheduled sessions and an average of 10 weeks to complete the intervention. Pre-intervention versus post-intervention V̇O

conclusionsThis is the first study to report the feasibility of HIIT in KTRs. Although participants struggled to achieve the required intensity (power), this study highlights the potential that exercise has to reduce cardiovascular risk in KTRs. HIIT and MICT performed on a cycle, with some modification, could be considered safe and feasible in KTRs. Larger scale trials are required to assess the efficacy of HIIT in KTRs and in particular identify the most appropriate intensities, recovery periods, and session duration. Some flexibility in delivery, such as incorporating home-based sessions, may need to be considered to improve recruitment and retention.

trial registrationISRCTN, ISRCTN17122775 . Registered on 30 January 2017.

Indexed as

Cardiovascular diseaseChronic kidney diseaseFeasibilityHigh-intensity interval trainingKidney transplantation

Identifiers

PMID35597974
PMCPMC9123685
OpenAlexW4281250899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.