Evidence map›Paper›PMID 35597921›Full record

ArticleBMC cancer2022

Development and technical validation of an ultrasound nebulizer to deliver intraperitoneal pressurized aerosols in a rat colon cancer peritoneal metastases model.

Jonathan R Buggisch, Daniel Göhler, Julien Sobilo, Stéphanie Lerondel, Günther A Rezniczek, Michael Stintz, Andreas Rudolph, Nicolas Tabchouri, Sébastien Roger, Mehdi Ouaissi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Jonathan R BuggischUniversity of Münster, Medizinische Fakultät, Münster, Germany.
Daniel GöhlerResearch Group Mechanical Process Engineering, Institute of Process Engineering and Environmental Technology, Technische Universität Dresden, Dresden, Germany.
Julien SobiloCNRS UPS44, CIPA, PHENOMIN-TAAM, Orléans, France.
Stéphanie LerondelCNRS UPS44, CIPA, PHENOMIN-TAAM, Orléans, France.
Günther A RezniczekDepartment of Obstetrics and Gynecology, Marien Hospital Herne, Ruhr-Universität Bochum, Bochum, Germany.
Michael StintzResearch Group Mechanical Process Engineering, Institute of Process Engineering and Environmental Technology, Technische Universität Dresden, Dresden, Germany.
Andreas RudolphTechnologie-orientierte Partikel-, Analysen- und Sensortechnik, Topas GmbH, Dresden, Germany.
Nicolas TabchouriDepartment of Digestive, Oncological, Endocrine, Hepato-Biliary, Pancreatic and Liver Transplant Surgery, University Hospital of Tours, Lille, France.
Sébastien RogerEA4245 Transplantation, Immunologie, Inflammation, Université de Tours, France.
Mehdi OuaissiDepartment of Digestive, Oncological, Endocrine, Hepato-Biliary, Pancreatic and Liver Transplant Surgery, University Hospital of Tours, Lille, France.
Urs Giger-PabstEA4245 Transplantation, Immunologie, Inflammation, Université de Tours, France. ursgiger@gmx.net.
Université de Tours · FRCentre National de la Recherche Scientifique · FRTU Dresden · DECentre Hospitalier Universitaire de Tours · FRUniversitätsklinik Marien Hospital Herne · DEUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimTo develop and validate a nebulizer device for anti-cancer research on pressurized intraperitoneal aerosol supply in a preclinical peritoneal metastases (PM) rat model. MATERIAL AND

methodsFor aerosol generation, an ultrasonic nebulizer (USN) was modified. Aerosol analyses were performed ex-vivo by laser diffraction spectrometry (LDS). Intraperitoneal (IP)

resultsThe USN was able to establish a stable and reproducible capnoperitoneum at a pressure of 8 to 10 mmHg. LDS showed that the USN provides a polydisperse and monomodal aerosol with a volume-weighted diameter of 2.6 μm. At a CO

conclusionsThe USN together with the PM rat model are suitable for robust and species-specific preclinical pharmacological studies regarding intraperitoneal delivery of pressurized aerosolized drugs and cancer research.

Indexed as

Colonic NeoplasmsPeritoneal NeoplasmsAerosolsAnimalsFluorodeoxyglucose F18HumansNebulizers and VaporizersRatsAerosolsFluorodeoxyglucose F18Human colorectal cancer cellsIntraperitoneal pressurized aerosolOrthotopic rat modelPeritoneal metastasisUltrasonic nebulizer

Identifiers

PMID35597921
PMCPMC9124413
OpenAlexW4281254222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.