ArticleJournal of molecular neuroscience : MN2022
Effects of Treadmill Exercise on Social Behavior in Rats Exposed to Thimerosal with Respect to the Hippocampal Level of GluN1, GluN2A, and GluN2B.
Article in Journal of molecular neuroscience : MN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Investigating the effects of different exercise protocols on depressive-like behaviors and brain-derived neurotrophic factor (BDNF) in rodents: a systematic review.Experimental brain research · 2026Pooled it
- Gallic acid partially attenuates thiomersal-associated oxidative, apoptotic, and CREB/BDNF-related alterations in rat hippocampal and prefrontal cortex tissues and systemic inflammatory responses.Molecular and cellular biochemistry · 2026Article
- Voluntary Exercise and Hippocampal Memory Enhancement: Decoding the Molecular Blueprint.Journal of molecular neuroscience : MN · 2026Review
- Effects of Exercise Type and Sertraline on Anxiety and Social Behavior in a Female Rat Model of PTSD.Brain and behavior · 2026Article
- Enhancement of Vitamin C's Protective Effect against Thimerosal-Induced Neurotoxicity in the Cerebral Cortex of Wistar Albino Rats: AnACS omega · 2024Article
- Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder.Frontiers in psychiatry · 2024Review
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thimerosal (THIM) kills brain neurons via induction of apoptosis and necrosis and induces the pathological features of autism spectrum disorder (ASD) in rats. THIM also affects the function of glutamatergic receptors. On the other hand, exercise induces both improvement and impairment effects on memory, depending on intensity, type, and duration. Treadmill exercise can also alter the expression of glutamatergic receptors. In this study, we aimed to investigate the effect of THIM and three protocols of treadmill exercise on social interaction memory and hippocampal expression of GluN1, GluN2A, and GluN2B in rats. THIM was injected intramuscularly at the dose of 300 µg/kg. The three-chamber apparatus was used to evaluate social interaction memory, and western blotting was used to assess protein expression. The results showed that THIM impaired social memory. Exercise 1 impaired social affiliation in controls. Social memory was impaired in all exercise groups of controls. Exercise 1 + 2 impaired social affiliation in THIM rats. Social memory was impaired in all groups of THIM rats. Exercises 2 and 1 + 2 decreased the expression of GluN1, and exercise 1 increased the expression of GluN2A and GluN2B in controls. THIM increased the expression of GluN2B, while exercise 1 reversed this effect. All exercise protocols increased the expression of GluN2A, and exercises 2 and 1 + 2 increased the expression of GluN1 in THIM rats. In conclusion, both THIM and exercise impaired social memory. Of note, the results did not show a separate and influential role for glutamatergic subunits in modulating memory processes following THIM injection or exercise.
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