ArticleScientific reports2022
Indocyanine green fluorescence image processing techniques for breast cancer macroscopic demarcation.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fluorescence guided surgery imaging systems for breast cancer identification: a systematic review.Journal of biomedical optics · 2024Pooled it
- Architecture-Dependent Stability, Cellular Uptake, and Redox Modulation of Poly(p-Coumaric Acid) Hybrid Nanoparticles for Ovarian Carcinoma Intervention.ACS nano medicine · 2026Article
- Intraoperative measurement of breast-conserving surgery margins: surgical application.Breast cancer research : BCR · 2026Review
- Effects of OACS applied bio materials · 2026Article
- Article
- A Low-Cost Optomechatronic Diffuse Optical Mammography System for 3D Image Reconstruction: Proof of Concept.Diagnostics (Basel, Switzerland) · 2025Article
- Technologies and techniques to improve precision in breast conserving surgery.Journal of surgical oncology · 2025Review
- Intraoperative near infrared functional imaging of rectal cancer using artificial intelligence methods - now and near future state of the art.European journal of nuclear medicine and molecular imaging · 2024Review
- Diagnosis and treatment status of inoperable locally advanced breast cancer and the application value of inorganic nanomaterials.Journal of nanobiotechnology · 2024Review
- Feasibility of indocyanine green (ICG) fluorescence inPathology oncology research : POR · 2024Article
- Article
- Contrast-Enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Tract.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Indocyanine Green Fluorescence Imaging in the Surgical Management of Skin Squamous Cell Carcinoma.Clinical, cosmetic and investigational dermatology · 2023Article
- Recent advances in optical imaging through deep tissue: imaging probes and techniques.Biomaterials research · 2022Review
- Overview of Biofluids and Flow Sensing Techniques Applied in Clinical Practice.Sensors (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Re-operation due to disease being inadvertently close to the resection margin is a major challenge in breast conserving surgery (BCS). Indocyanine green (ICG) fluorescence imaging could be used to visualize the tumor boundaries and help surgeons resect disease more efficiently. In this work, ICG fluorescence and color images were acquired with a custom-built camera system from 40 patients treated with BCS. Images were acquired from the tumor in-situ, surgical cavity post-excision, freshly excised tumor and histopathology tumour grossing. Fluorescence image intensity and texture were used as individual or combined predictors in both logistic regression (LR) and support vector machine models to predict the tumor extent. ICG fluorescence spectra in formalin-fixed histopathology grossing tumor were acquired and analyzed. Our results showed that ICG remains in the tissue after formalin fixation. Therefore, tissue imaging could be validated in freshly excised and in formalin-fixed grossing tumor. The trained LR model with combined fluorescence intensity (pixel values) and texture (slope of power spectral density curve) identified the tumor's extent in the grossing images with pixel-level resolution and sensitivity, specificity of 0.75 ± 0.3, 0.89 ± 0.2.This model was applied on tumor in-situ and surgical cavity (post-excision) images to predict tumor presence.
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Registered trials
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