ArticleThe Journal of chemical physics2022
Multiphase organization is a second phase transition within multi-component biomolecular condensates.
Article in The Journal of chemical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 13 citations in OpenAlex.
- Fundamental Aspects of Phase-Separated Biomolecular Condensates.Chemical reviews · 2024Review
- GENESIS CGDYN: large-scale coarse-grained MD simulation with dynamic load balancing for heterogeneous biomolecular systems.Nature communications · 2024Article
- SpiDec: Computing binodals and interfacial tension of biomolecular condensates from simulations of spinodal decomposition.Frontiers in molecular biosciences · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
We present a mean-field theoretical model, along with molecular dynamics simulations, to show that the multiphase organization of multi-component condensates is a second phase transition. Whereas the first phase transition that leads to the separation of condensates from the bulk phase is driven by the overall attraction among the macromolecular components, the second phase transition can be driven by the disparity in the strength between the self- and cross-species attraction. At a fixed level of disparity in interaction strengths, both of the phase transitions can be observed by decreasing the temperature, leading first to the separation of condensates from the bulk phase and then to component demixing inside condensates. The existence of a critical temperature for demixing and predicted binodals are verified by molecular dynamics simulations of model mixtures.
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