Evidence map›Paper›PMID 35597370›Full record

Trial reportThe Journal of allergy and clinical immunology2022

Socioeconomic status associates with worse asthma morbidity among Black and Latinx adults.

Juan Carlos Cardet, Ku-Lang Chang, Benjamin J Rooks, Jennifer K Carroll, Juan Carlos Celedón, Tamera Coyne-Beasley, Jing Cui, Brianna Ericson, Victoria E Forth, Maureen Fagan and 12 more

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The Journal of allergy and clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 36 citations in OpenAlex.

  1. Trial
  2. Socioeconomic status and acculturation as determinants of atopic disease prevalence in United States Latino children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Asthma Inception: Epidemiologic Risk Factors and Natural History Across the Life Course.American journal of respiratory and critical care medicine · 2024
    Review
  13. The Role of Neighborhood Air Pollution in Disparate Racial and Ethnic Asthma Acute Care Use.American journal of respiratory and critical care medicine · 2024
    Article
  14. Article
  15. Asthma morbidity measures across Black ethnic subgroups.The Journal of allergy and clinical immunology · 2024
    Article
  16. Review
  17. Article
  18. Observational
  19. Article
  20. New considerations of health disparities within allergy and immunology.The Journal of allergy and clinical immunology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 10 institutions in 1 country.

Juan Carlos CardetDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Fla.
Ku-Lang ChangDepartment of Community Health and Family Medicine, University of Florida College of Medicine, Gainesville, Fla.
Benjamin J RooksDepartment of Community Health and Family Medicine, University of Florida College of Medicine, Gainesville, Fla.
Jennifer K CarrollAmerican Academy of Family Physicians, National Research Network, Leawood, Kan; CU Anschutz Department of Family Medicine, University of Colorado, Aurora, Colo.
Juan Carlos CeledónDivision of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pa.
Tamera Coyne-BeasleyDepartment of Medicine, University of Alabama at Birmingham, Children's of Alabama, Birmingham.
Jing CuiDivisions of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Mass.
Brianna EricsonPulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Mass.
Victoria E ForthPulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Mass.
Maureen FaganUniversity of Miami Health System, Miami, Fla.
Anne L FuhlbriggeDepartment of Medicine, Pulmonary Science and Critical Care Medicine, University of Colorado School of Medicine, Aurora, Colo.
Paulina Arias HernandezDivisions of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Mass.
Jean KruseDivisions of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Mass.
Margee LouisiasDivision of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Mass.
Nancy E MaherDivisions of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Mass.
Brian ManningAmerican Academy of Family Physicians, National Research Network, Leawood, Kan.
Wilson D PaceAmerican Academy of Family Physicians, National Research Network, Leawood, Kan; DARTNet Institute, Aurora, Colo.
Wanda PhipatanakulBoston Children's Hospital, Boston, Mass.
Jacqueline Rodriguez-LouisDivisions of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Mass.
Joel B ShieldsAmerican Academy of Family Physicians, National Research Network, Leawood, Kan.
Elliot IsraelDivisions of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Mass; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Mass. Electronic address: eisrael@bwh.harvard.edu.
Juan P WisniveskyDivisions of General Internal Medicine and Pulmonary and Critical Care Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Brigham and Women's Hospital · USAmerican Academy of Family Physicians · USUniversity of Florida · USBoston Children's Hospital · USChildren's of Alabama · USIcahn School of Medicine at Mount Sinai · USUniversity of Colorado Denver · USUniversity of Miami Health System · USUniversity of Pittsburgh · USUniversity of South Florida · US

Funding

Midcareer Investigator Award: Urban School Allergen Exposures and Childhood AsthmK24AI106822 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2013 to 2022
$1.9M
Enterolactone and AsthmaK23AI125785 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CARDET, JUAN CARLOS · 2017 to 2021
$970k
NHLBI NIH HHS L30 HL143781NIAID NIH HHS K23 AI125785NIAID NIH HHS K24 AI106822
6 · The paper itself

Abstract

backgroundAsthma disproportionately affects African American/Black (AA/B) and Hispanic/Latinx (H/L) patients and individuals with low socioeconomic status (SES), but the relationship between SES and asthma morbidity within these racial/ethnic groups is inadequately understood.

objectiveTo determine the relationship between SES and asthma morbidity among AA/B and H/L adults with moderate to severe asthma using multidomain SES frameworks and mediation analyses.

methodsWe analyzed enrollment data from the PeRson EmPowered Asthma RElief randomized trial, evaluating inhaled corticosteroid supplementation to rescue therapy. We tested for direct and indirect relationships between SES and asthma morbidity using structural equation models. For SES, we used a latent variable defined by poverty, education, and unemployment. For asthma morbidity, we used self-reported asthma exacerbations in the year before enrollment (corticosteroid bursts, emergency room/urgent care visits, or hospitalizations), and Asthma Control Test scores. We tested for mediation via health literacy, perceived stress, and self-reported discrimination. All models adjusted for age, sex, body mass index, ethnicity, and comorbidities.

resultsAmong 990 AA/B and H/L adults, low SES (latent variable) was directly associated with hospitalizations (β = 0.24) and worse Asthma Control Test scores (β = 0.20). Stress partially mediated the relationship between SES and increased emergency room/urgent care visits and worse asthma control (β = 0.03 and = 0.05, respectively). Individual SES domains were directly associated with asthma morbidity. Stress mediated indirect associations between low educational attainment and unemployment with worse asthma control (β = 0.05 and = 0.06, respectively).

conclusionsLower SES is directly, and indirectly through stress, associated with asthma morbidity among AA/B and H/L adults. Identification of stressors and relevant management strategies may lessen asthma-related morbidity among these populations.

Indexed as

AsthmaSocial ClassAdrenal Cortex HormonesAdultBlack or African AmericanHumansMorbidityAdrenal Cortex Hormonesasthma exacerbationsdiscriminationeducationemploymenthealth literacyincomemediation analysisMinority populationssevere persistent asthmastressstructural equation models

Identifiers

PMID35597370
PMCPMC9724153
OpenAlexW4280582928

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.