ArticleCerebral cortex (New York, N.Y. : 1991)2023
Long-range functional connections mirror and link microarchitectural and cognitive hierarchies in the human brain.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Integrating Neuroimaging and Machine Learning to Predict Mental Disorder Outcomes: A Systematic Review.Advances in experimental medicine and biology · 2026Pooled it
- TE-aware state analysis and evolution in dynamic network connectivity.bioRxiv : the preprint server for biology · 2026Article
- Individual differences reveal distinct age and pubertal contributions to the refinement of the functional cortical hierarchy during adolescence.bioRxiv : the preprint server for biology · 2026Article
- Functional connectome gradient alterations in herpes zoster and postherpetic neuralgia: associations with gene expression profiles.The journal of headache and pain · 2026Article
- Bridging glucose metabolism and intrinsic functional organization of the human cortex.Communications biology · 2026Article
- Cortical morphometric gradients reveal molecular and cognitive underpinnings of bipolar disorder.Psychological medicine · 2025Article
- Sensory reformatting for a working visual memory.Trends in cognitive sciences · 2025Review
- Abnormal cortical topographic patterns associated with auditory verbal hallucination in first-episode schizophrenia.Translational psychiatry · 2025Article
- Anterior-posterior systematic deficits of cortical thickness in early-onset schizophrenia.Communications biology · 2025Article
- Neurogenetic phenotypes of learning-dependent plasticity for improved perceptual decisions.Communications biology · 2025Article
- Multimodal gradients unify local and global cortical organization.Nature communications · 2025Article
- Motor Functional Hierarchical Organization of Cerebrum and Its Underlying Genetic Architecture in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cytoarchitectonic gradients of laminar degeneration in behavioural variant frontotemporal dementia.Brain : a journal of neurology · 2025Article
- Lesion-network mapping in task-dependent frequencies uncovers remote consequences of focal damage.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Comparing structure-function relationships in brain networks using EEG and fNIRS.Scientific reports · 2024Article
- Lateral prefrontal cortex controls interplay between working memory and actions.bioRxiv : the preprint server for biology · 2024Article
- Contracted functional connectivity profiles in autism.Molecular autism · 2024Article
- Sex differences in functional cortical organization reflect differences in network topology rather than cortical morphometry.Nature communications · 2024Article
- Deciphering the functional specialization of whole-brain spatiomolecular gradients in the adult brain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Radiomic white matter parameters of functional integrity of the corticospinal tract in high-grade glioma.Scientific reports · 2024Article
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14 authors.
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Abstract
backgroundHigher-order cognition is hypothesized to be implemented via distributed cortical networks that are linked via long-range connections. However, it is unknown how computational advantages of long-range connections reflect cortical microstructure and microcircuitry.
methodsWe investigated this question by (i) profiling long-range cortical connectivity using resting-state functional magnetic resonance imaging (MRI) and cortico-cortical geodesic distance mapping, (ii) assessing how long-range connections reflect local brain microarchitecture, and (iii) examining the microarchitectural similarity of regions connected through long-range connections.
resultsAnalysis of 2 independent datasets indicated that sensory/motor areas had more clustered short-range connections, while transmodal association systems hosted distributed, long-range connections. Meta-analytical decoding suggested that this topographical difference mirrored shifts in cognitive function, from perception/action towards emotional/social processing. Analysis of myelin-sensitive in vivo MRI as well as postmortem histology and transcriptomics datasets established that gradients in functional connectivity distance are paralleled by those present in cortical microarchitecture. Notably, long-range connections were found to link spatially remote regions of association cortex with an unexpectedly similar microarchitecture.
conclusionsBy mapping covarying topographies of long-range functional connections and cortical microcircuits, the current work provides insights into structure-function relations in human neocortex.
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