Evidence map›Paper›PMID 35596909›Full record

ArticleCardiovascular toxicology2022

Impact of DYRK1A Expression on TNNT2 Splicing and Daunorubicin Toxicity in Human iPSC-Derived Cardiomyocytes.

Romina Beatriz Cejas, Miriam Tamaño-Blanco, John Edgar Fontecha, Javier Guillermo Blanco

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Anthracycline Toxicity: Light at the End of the Tunnel?Annual review of pharmacology and toxicology · 2024
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Romina Beatriz CejasDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, NY, 14214, USA.
Miriam Tamaño-BlancoDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, NY, 14214, USA.
John Edgar FontechaGroup for Applied Mathematical Modeling and Analytics (GAMMA), Industrial and Systems Engineering, The State University of New York at Buffalo, Buffalo, NY, 14214, USA.
Javier Guillermo BlancoDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, NY, 14214, USA. jgblanco@buffalo.edu.
University at Buffalo, State University of New York · US

Funding

PHARMACOGENETICS OF HUMAN CARBONYL REDUCTASESR01GM073646 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BLANCO, JAVIER GUILLERMO · 2005 to 2019
$4.1M
Evaluation of myocardial targets to prevent anthracycline cardiotoxicity in children with Down Syndrome and LeukemiaR21CA245067 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BLANCO, JAVIER GUILLERMO · 2019 to 2020
$439k
Epigenetic Regulation of FcRn Expression in Human Lung and its Role in the Disposition of Monoclonal Antibody DrugsR21HD089053 · NICHD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BLANCO, JAVIER GUILLERMO · 2017 to 2018
$398k
NCI NIH HHS R21 CA245067NICHD NIH HHS R21 HD089053NIGMS NIH HHS R01 GM073646
6 · The paper itself

Abstract

Cardiac troponin T (encoded by TNNT2) is involved in the contraction of cardiomyocytes during beating. The alternative splicing of TNNT2 results in four transcript variants with differential Ca

Indexed as

Induced Pluripotent Stem CellsMyocytes, CardiacAdultCardiotoxicityDaunorubicinDyrk KinasesHumansPhosphoproteinsProtein Serine-Threonine KinasesProtein-Tyrosine KinasesSerine-Arginine Splicing FactorsTroponin TDaunorubicinDyrk KinasesPhosphoproteinsProtein Serine-Threonine KinasesProtein-Tyrosine KinasesSerine-Arginine Splicing FactorsSRSF6 protein, humanTNNT2 protein, humanTroponin TAlternative splicingAnthracyclinesCardiotoxicityHeartHuman cardiomyocytesTroponin

Identifiers

PMID35596909
PMCPMC9236996
OpenAlexW4281251146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.