SynthesisTechniques in coloproctology2022
Early vs. standard reversal ileostomy: a systematic review and meta-analysis.
Synthesis in Techniques in coloproctology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Early versus late closure of protective ileostomy after rectal cancer surgery.International journal of colorectal disease · 2026Pooled it
- Safety and feasibility of early discharge (≤ 23 h) following loop ileostomy reversal: a systematic review and meta-analysis.International journal of colorectal disease · 2026Pooled it
- Risk factors and incidence of surgical wound infection after stoma reversal: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Prevalence and risk factors for postoperative ileus in colorectal cancer patients: a systematic review and meta-analysis.Frontiers in oncology · 2025Pooled it
- Quality of life following ileostomy takedown: single-centre, retrospective clinical trial-does closure time matter?Techniques in coloproctology · 2025Trial
- Clinical application of the B-type sutured ileostomy in robotic-assisted low anterior resection for rectal cancer: a propensity score matching analysis.Journal of robotic surgery · 2024Trial
- Delayed Loop Ileostomy Reversal Increases the Risk of Colitis and Clostridium difficile Infection.ANZ journal of surgery · 2026Article
- Optimal timing of ileostomy closure after rectal surgery: A Bayesian network meta-analysis of randomized controlled trials.Langenbeck's archives of surgery · 2026Review
- Performance and safety of the Colovac 2 colorectal anastomotic protection device: the SafeHeal SAFE-2023 study.Surgical endoscopy · 2026Article
- Impact of timing of ileostomy reversal and anastomotic leakage on bowel function and health-related quality of life following rectal cancer surgery: a cross-sectional study.Surgical endoscopy · 2026Article
- Effect and influencing factors of early ileostomy closure 2-4 weeks on patients with rectal cancer.Frontiers in oncology · 2026Article
- Timing of diverting loop ileostomy closure after rectal resection: Commentary on recent findings.World journal of gastrointestinal surgery · 2025Article
- Ileostomy closure at an ambulatory surgery center: an initial assessment of feasibility and safety.Surgical endoscopy · 2025Article
- Relationship between core symptoms, function, and quality of life in colorectal cancer patients: a network analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Stoma reversal after emergency stoma formation-the importance of timing: a multi-centre retrospective cohort study.World journal of emergency surgery : WJES · 2025Article
- Timing and morbidity of loop ileostomy closure after rectal cancer resection: a prospective observational multicentre snapshot study from Multidisciplinary Italian Study group for STOmas (MISSTO).International journal of colorectal disease · 2025Observational
- Increased risk of postoperative complications after delayed stoma reversal: a multicenter retrospective cohort study on patients undergoing anterior resection for rectal cancer.International journal of colorectal disease · 2025Article
- Independent risk factors for diversion colitis: a retrospective case-control study.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Complicated diverticulitis: Diagnostic precision and surgical solutions in a patient with chronic kidney disease.Radiology case reports · 2025Article
- Early Closure of Diverting Ileostomy After Rectal Resection: Are We Ready to Make the Shift?Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2025Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFormation of a defunctioning loop ileostomy is common after mid and low rectal resection. Historically, they were reversed between 3 and 6 months after initial resection. Recently, earlier closure (< 14 days) has been suggested by some current randomised controlled trials. The aim of this study was to investigate the effect of early stoma closure on surgical and patient outcomes.
methodsA systematic review of the current randomised controlled trial literature comparing early and standard ileostomy closure after rectal surgery was performed. Specifically, we examined surgical outcomes including; morbidity, mortality and quality of life.
resultsSix studies met the predefined criteria and were included in our analysis. 275 patients underwent early stoma closure compared with 259 patients having standard closure. Overall morbidity was similar between both groups (25.5% vs. 21.6%) (OR, 1.47; 95% CI 0.75-2.87). However, there tended to be more reoperations (8.4 vs. 4.2%) (OR, 2.02, 95% CI 0.99-4.14) and small bowel obstructions/postoperative ileus (9.3% vs. 4.4%) (OR 0.44, 95% CI 0.22-0.90) in the early closure group, but no difference across the other domains.
conclusionsEarly closure appears to be a feasible in highly selective cases after good perioperative counselling and shared decision-making. Further research on quality of life outcomes and long term benefits is necessary to help define which patients are suitable candidates for early closure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.