Evidence map›Paper›PMID 35596900›Full record

ArticleJournal of gambling studies2022

"A Theta Burst Stimulation on Pre-SMA: Proof-of-Concept of Transcranial Magnetic Stimulation in Gambling Disorder".

Luana Salerno, Eleonora Grassi, Nikos Makris, Stefano Pallanti

Open access · greenAbstract read
In one paragraph

Article in Journal of gambling studies, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Luana SalernoIstituto di Neuroscienze, Florence, Italy. salerno.luana@gmail.com.
Eleonora GrassiIstituto di Neuroscienze, Florence, Italy. eleonora.grassi90@gmail.com.
Nikos MakrisDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Stefano PallantiAlbert Einstein College of Medicine, Bronx, New York, USA.
Neuroscience Institute · ITAlbert Einstein College of Medicine · USMassachusetts General Hospital · US

Funding

Mentoring and neuroimaging research on new targets for DBS in OCDK24MH116366 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MAKRIS, NIKOLAOS · 2018 to 2022
$817k
Modulating Inhibitory Control Networks In Gambling Disorder With Theta Burst StimulationR21DA042271 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI CAMPRODON, JOAN A, MAKRIS, NIKOLAOS · 2017 to 2018
$439k
COMPUTED TOMOGRAPHY STUDY IN SCHIZOPHRENIAR01MH042271 · NIMH · LONG ISLAND JEWISH MEDICAL CENTER · PI LIEBERMAN, JEFFREY A · 1987 to 1989
–
NIDA NIH HHS R21 DA042271NIMH NIH HHS K24 MH116366NIMH NIH HHS R21DA042271
6 · The paper itself

Abstract

Gambling Disorder (GD) is a condition constituting a public health concern, with a burden of harm which is much greater than that of drug addiction. Patients with GD are generally reluctant to pharmacologic treatment and seem to prefer nonpharmacological interventions. Therefore, this proof-of-concept study aimed to investigate the feasibility of continuous Theta Burst Stimulation (cTBS) on the pre-SMA in six patients (5 males, 1 female), aged 30-64 years, with a DSM-5 diagnosis of Gambling Disorder and no comorbid mood disorders. Participants received over 10 sessions of Continuous TBS (cTBS) over pre-SMA bilaterally and have been evaluated using rating scales, including the PG-YBOCS and the CGI, before treatment (T0), at day 10 of treatment (T1) and at day 30 after treatment (T2); cTBS intervention was safe and without side effects. Since the design of our study does not allow us to draw conclusions on the effectiveness of the intervention with respect to the improvement of the functioning of the subject with GD, a more in-depth study, including a sham condition, neurocognitive measures of disinhibition and decision making, and collecting follow-up data on the sustained effect of TBS over a longer period is ongoing.

Indexed as

GamblingMotor CortexDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleTranscranial Magnetic StimulationGambling disorderNeuromodulationNeuroplasticityPre-supplementary motor areatheta-burst stimulation

Identifiers

PMID35596900
PMCPMC9123619
OpenAlexW4281258420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.