Evidence map›Paper›PMID 35596705›Full record

SynthesisClinical transplantation2022

The role of T-tubes and abdominal drains on short-term outcomes in liver transplantation - A systematic review of the literature and expert panel recommendations.

Marit Kalisvaart, Jeroen de Jonge, Peter Abt, Susan Orloff, Paolo Muiesan, Sander Florman, Michael Spiro, Dimitri Aristotle Raptis, Bijan Eghtesad, ERAS4OLT.org working group

Open access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Clinical transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 5 countries.

Marit KalisvaartDepartment of General Surgery & Transplantation, University Hospital Zurich, Zurich, Switzerland.
Jeroen de JongeErasmus MC Transplant Institute, Division of HPB and Transplant Surgery, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Peter AbtDepartment of Surgery, Division of Transplantation, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Susan OrloffDepartment of Surgery, Division of Abdominal Organ Transplantation/ Hepatobiliary Surgery, Oregon Health & Science University, Portland, Oregon, USA.
Paolo MuiesanPoliclinico di Milano Ospedale Maggiore | Fondazione IRCCS Ca' Granda, Milan, Italy.
Sander FlormanThe Recanati Miller Transplantation Institute, Mount Sinai School of Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0002-1635-9136
Michael SpiroDepartment of Anesthesia and Intensive Care Medicine, Royal Free Hospital, London, UK.
Dimitri Aristotle RaptisClinical Service of HPB Surgery and Liver Transplantation, Royal Free Hospital, London, UK.
Bijan EghtesadTransplantation Center, Department of Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-7857-0092
ERAS4OLT.org working groupDepartment of General Surgery & Transplantation, University Hospital Zurich, Zurich, Switzerland.
The Royal Free Hospital · GBCleveland Clinic · USErasmus MC · NLFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHospital of the University of Pennsylvania · USMount Sinai Hospital · USOregon Health & Science University · USUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis systematic review and expert panel recommendation aims to answer the question regarding the routine use of T-tubes or abdominal drains to better manage complications and thereby improve outcomes after liver transplantation.

methodsSystematic review following PRISMA guidelines and recommendations using the GRADE approach derived from an international expert panel to assess the potential risks and benefits of T-tubes and intra-abdominal drainage in liver transplantation (CRD42021243036).

resultsOf the 2996 screened records, 33 studies were included in the systematic review, of which 29 (six RCTs) assessed the use of T-tubes and four regarding surgical drains. Although some studies reported less strictures when using a T-tube, there was a trend toward more biliary complications with T-tubes, mainly related to biliary leakage. Due to the small number of studies, there was a paucity of evidence on the effect of abdominal drains with no clear benefit for or against the use of drainage. However, one study investigating the open vs. closed circuit drains found a significantly higher incidence of intra-abdominal infections when open-circuit drains were used.

conclusionsDue to the potential risk of biliary leakage and infections, the routine intraoperative insertion of T-tubes is not recommended (Level of Evidence moderate - very low; grade of recommendation strong). However, a T-tube can be considered in cases at risk for biliary stenosis. Due to the scant evidence on abdominal drainage, no change in clinical practice in individual centers is recommended. (Level of Evidence very low; weak recommendation).

Indexed as

Biliary Tract DiseasesLiver TransplantationAbdomenDrainageHumansPostoperative Complicationsabdominal drainagebiliary complicationsbiliary leakagebiliary stricturescomplicationsliver transplantationoutcomesT-tubes

Identifiers

PMID35596705
PMCPMC10078006
OpenAlexW4281250539

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.