Evidence map›Paper›PMID 35596578›Full record

ArticleJournal of psychopharmacology (Oxford, England)2022

Individual and combined effects of cannabidiol and Δ

Matthew B Wall, Tom P Freeman, Chandni Hindocha, Lysia Demetriou, Natalie Ertl, Abigail M Freeman, Augustus Pm Jones, Will Lawn, Rebecca Pope, Claire Mokrysz and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Acute effects of different types of cannabis on young adult and adolescent resting-state brain networks.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Update of the statement on safety of cannabidiol as a novel food.EFSA journal. European Food Safety Authority · 2026
    Article
  9. Review
  10. Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Matthew B WallInvicro London, London, UK.ORCID 0000-0002-0493-6274
Tom P FreemanClinical Psychopharmacology Unit, University College London, London, UK.
Chandni HindochaClinical Psychopharmacology Unit, University College London, London, UK.
Lysia DemetriouInvicro London, London, UK.ORCID 0000-0001-5249-0900
Natalie ErtlInvicro London, London, UK.
Abigail M FreemanClinical Psychopharmacology Unit, University College London, London, UK.ORCID 0000-0003-2465-0174
Augustus Pm JonesDivision of Psychiatry, University College London, London, UK.
Will LawnClinical Psychopharmacology Unit, University College London, London, UK.ORCID 0000-0002-0143-2724
Rebecca PopeClinical Psychopharmacology Unit, University College London, London, UK.
Claire MokryszClinical Psychopharmacology Unit, University College London, London, UK.
Daniel SolomonsFaculty of Medicine, Imperial College London, London, UK.
Ben StattonMRC London Institute of Medical Sciences, London, UK.
Hannah R WalkerDivision of Psychiatry, University College London, London, UK.
Yumeya YamamoriDivision of Psychiatry, University College London, London, UK.
Zixu YangFaculty of Medicine, Imperial College London, London, UK.
Jocelyn Ll YimDivision of Psychiatry, University College London, London, UK.
David J NuttFaculty of Medicine, Imperial College London, London, UK.
Oliver D HowesMRC London Institute of Medical Sciences, London, UK.
H Valerie CurranClinical Psychopharmacology Unit, University College London, London, UK.
Michael Ap BloomfieldDivision of Psychiatry, University College London, London, UK.ORCID 0000-0002-1972-4610
University College London · GBImperial College London · GBInvicro (United Kingdom) · GBKing's College London · GBMRC London Institute of Medical Sciences · GBUniversity of Oxford · GB

Funding

Medical Research Council MC_U120097115Medical Research Council MR/N027078/1
6 · The paper itself

Abstract

backgroundCannabidiol (CBD) and Δ

aimsTo examine effects of THC, CBD, and THC + CBD on functional connectivity of striatal sub-divisions (associative, limbic and sensorimotor).

methodResting-state functional Magnetic Resonance Imaging (fMRI) was used across two within-subjects, placebo-controlled, double-blind studies, with a unified analysis approach.

resultsStudy 1 ( OUTCOMES: THC strongly disrupts striato-cortical networks, but this effect is mitigated by co-administration of CBD in the limbic striatum network. Oral CBD administered has a more complex effect profile of relative increases and decreases in connectivity. The insula emerges as a key region affected by cannabinoid-induced changes in functional connectivity, with potential implications for understanding cannabis-related disorders, and the development of cannabinoid therapeutics.

Indexed as

CannabidiolCannabinoidsCannabisHallucinogensBrainCannabinoid Receptor AgonistsDouble-Blind MethodDronabinolHumansCannabidiolCannabinoid Receptor AgonistsCannabinoidsDronabinolHallucinogensCannabinoidscannabisCBDfMRIresting-stateTHC

Identifiers

PMID35596578
PMCPMC9150138
OpenAlexW4281253922

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.